Original Arbeiten

 

-2017-

IF

90.

Boccaletto, P., Machnicka, M.A., Purta, E., Piatkowski, P., Baginski, B., Wirecki, T.K., de Crécy-Lagard, V., Ross, R., Limbach, P.A., Kotter, A., Helm, M., Bujnicki, J.M., MODOMICS: a database of RNA modification Pathways. 2017 update., (2017), Nucleic Acid Research., Nov. 2, Epub ahead of print, Full Text

 

PMID: 29106616

N/A

89.

Negwer, I., Hirsch, M., Kaloyanova, S., Brown, T., Peneva, K., Butt, H.J., Koynov, K., Helm, M.,  Modulation of Mitochondriotropic Properties of Cyanine Dyes by in Organello Copper-Free Click Reaction., (2017), Chembiochem., Sep. 19, 18(18):1814-1818, Full Text

 

PMID: 28704573

N/A

88.

Weber, B., Kappel, C., Scherer, M., Helm, M., Bros. M., Grabbe, S., Barz, M., PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes., (2017), Macromol Biosci., Jul. 31, 17(10), Full Text

 

PMID: 28759159

3,3

87.

Legrand, C., Tuorto, F., Hartmann, M., Liebers, R., Jacob, D., Helm, M., Lyko, F., Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs, (2017), Genome Res., Jul. 6, 27(9):1589-1596, Full text

 

PMID: 28684555

11,9

86.

Schmitt, F.C.F., Freund, I., Weigand, M.A., Helm, M., Dalpke, A.H., Eigenbrod, T., Identification of an optimized 2'-O-methylated tri-nucleotide RNA motif inhibiting Toll-like receptor 7 and 8, (2017), RNA, Jun. 2, 23(9):1344-1351, Full text

 

PMID: 28576825

4,6

85.

Hellmuth, I., Freund, I., Schlöder, J., Seidu-Larry, S., Thüring, K., Slama, K., Langhanki, J., Kaloyanova, S., Eigenbrod, T., Krumb, M., Röhm, S., Peneva K., Opatz, T., Jonuleit, H., Dalpke, A.H., Helm, M.,  Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor, (2017), 7. Fronti. Immunol., Mar. 24, 8:312, Full text

 

DOI: 10.3389/fimmu.2017.00312


5,7

84.

Schmid, K., Adobes-Vidal, M., Helm, M., Alkyne-Functionalized Coumarin Compound for Analytic and Preparative 4-Thiouridine Labeling, (2017), Bioconjugate Chemistry, Mar. 15, 28(4):1123-1134, Full text

 

PMID: 28263563


4,5

83.

Marchand, V., Pichot, F., Thüring, K., Avadi, L., Freund, I., Dalpke, A., Helm, M., Motorin, Y., Next-Generation Sequencing-Based RiboMethSeq Protocol for Analysis of tRNA 2'-O-Methylation, (2017), Biomolecules, Feb. 9, 7(1), Full text

 

PMID: 28208788


N/A

-2016-

IF

82.

Lence, T., Akhtar, J., Bayer, M., Schmid, K., Spindler, K., Ho, CH., Kreim, N., Andrade-Navarro, MA., Poeck, B., Helm, M., Roignant, JY., m6A modulates neuronal functions and sex determination in Drosophila, (2016), Nature, Dec. 8, 540(7632):242-247, Full text

 

PMID: 27919077


38,2

81.

Kaiser, S., Jurkowski, TP., Kellner, S., Schneider, D., Jeltsch, A., Helm, M., The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA, (2016) RNA Biology, Nov., 7:1-11, Full text

 

PMID: 27819523


4,1

80.

Hauenschild, R., Werner, S., Tserovski, L., Hildebrandt, A., Motorin, Y., Helm, M., CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles, (2016) Biomolecues., Nov. 10, 6(4), Full text

 

 

PMID: 27834909


N/A

79.

Falckenhayn, C., Carneiro, VC., de Mendonça Amarante, A., Schmid, K., Hanna, K., Kang, S., Helm, M., Dimopoulos, G., Fantappié, MR., Lyko, F., Comprehensive DNA methylation analysis of the Aedes aegypti genome, (2016) Sci. Rep., Nov. 2, 6:36444, Full text

 

PMID: 27805064


5,2

78.

Jüdes, A., Bruch, A., Klassen, R., Helm, M., Schaffrath, R.,  Sulfur transfer and activation by ubiquitin-like modifier system Uba4Urm1 link protein urmylation and tRNA thiolation in yeast, (2016), Microb Cell., Oct. 24, 3(11):554-564, Full text

 

PMID: 28357324 

N/A

77.

Müller, S., Fritz, T., Gimnich, M., Worm, M., Helm, M., Frey, H., Biodegradable Hyperbranched Polyether-Lipids with In-Chain pH-Sensitive Linkages, (2016) Polym. Chem., Sep. 19, Full text

 

DOI: 10.1039/C6PY01308B


5,7

76.

Tserovski, L., Helm, M.,Diastereoselectivity of 5-methyluridine osmylation is inverted inside an RNA chain., (2016) Bioconjugate Chemistry, Aug. 19, 27(9):2188-97, Full text

 

PMID: 27540864



4,5

75.

Fritz, T., Voigt, M., Worm, M., Negwer, I., Müller, SS., Kettenbach, K., Ross, TL., Roesch, F., Koynov, K., Frey, H., Helm, M., Orthogonal Click Conjugation to the Liposomal Surface Reveals the Stability of the Lipid Anchorage as Crucial for Targeting., (2016) Chemistry, Aug. 8, 22(33):11578-82 

 

PMID: 27403892


 5,8

74.

Nick, TA., de Oliverira, TE., Pilat, DW., Spenkuch, F., Butt, HJ., Helm, M., Netz, PA., Berger, R., Stability of a Split Streptomycin Binding Aptamer., (2016) The Journal of physical chemistry. B., Jul. 14, 120(27):6479-89 , Full text

 

PMID: 27281393


3,2

73.

Marchand, V., Blanloeil- Oillo, F., Helm, M., Motorin, Y., Illumina-based RiboMethSeq approach for mapping of 2'-O-Me residues in RNA., (2016) Nucleic Acid Research, Jun. 14, 44(16):e135, Full text

 

PMID: 27302133


9,1

-2015-

IF

72.

Kienhöfer, S., Musheev, MU., Stapf, U., Helm, M., Schomacher, L., Niehrs, C., Schäfer, A., (2015) GADD45a physically and functionally interacts with TET1. Differentiation, Nov. 03, 90(1-3):59-68, Full text

 

PMID: 26546041


 

 3,4

71.

Vogt, G., Falckenhayn, C., Schrimpf, A., Schmid, K., Hanna, K., Pantelein, J., Helm, M., Schulz, R., Lyko, F., (2015) The marbled crayfish as a paradigm for saltational speciation by autopolyploidy and parthenogenesis in animals. Biology Open, Oct. 30, 4(11):1583-94, Full Text

 

PMID: 26519519


 2,4

70.

Müller, M., Hartmann, M., Schuster, I., Bender, S., Thüring, KL., Helm, M., Katze, JR., Nellen, W., Lyko, F., Ehrenhofer-Murray, AE. (2015) Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine. Nucleic Acids Research, Sep. 30, 43(22):10952-62, Full text

 

PMID: 26424849

9,1

69.

Hauenschild, R., Tserovski, L., Schmid, K., Thüring, K., Winz, ML., Sharma, S., Entian, KD., Wacheul, L., Lafontaine, DL., Anderson, J., Alfonzo, J., Hildebrandt, A., Jäschke, A., Motorin, Y., Helm, M., (2015) The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent. Nucleic Acids Research, Sep. 13, 43(20):9950-64, Full text

 

PMID: 26365242

 

9,1

68.

Schmid, K., Thüring, K., Keller, P., Ochel, A., Kellner, S., Helm, M., (2015) Variable presence of 5-methylcytosine in commercial RNA and DNA. RNA Biology, Aug. 14, 12(10):1152-8, Full text

 

PMID: 26274337

 

5,0

67.

Bourgeois, G., Ney, M., Gaspar, I., Aiqueperse, C., Schaefer, M., Kellner, S., Helm, M., Motorin, Y. (2015) Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120.  PLoS One, Jul. 21, 10(7):e0133321, Full text

 

PMID: 26196125

 

3,2

66.

Shanmugam, R., Fierer, J., Kaiser, S., Helm, M., Jurkowski, T. P., Jeltsch, A. (2015) Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences. Cell Discovery, Jun. 9, 1, 1501, epub ahead of print, Full text

 

doi:10.1038/celldisc.2015.10

N/A

65.

 Domingo,O., Hellmuth, I., Jaeschke, A., Kreutz, C., Helm, M. (2015) Intermolecular 'cross-torque': the N4-cytosine propargyl residue is rotated to the 'CH'-edge as a result of Watson-Crick interaction. Nucleic Acids Research, Apr. 30, 43(11):5275-83, Full text

 

PMID: 25934805

9,1

64.

Hirsch, M. & Helm, M. (2015) Live cell imaging of duplex siRNA intracellular trafficking. Nucleic Acids Research, Apr. 13, 43(9):4650-60, Full text

PMID: 25870407

9,1

63.

Rimbach, K., Kaiser, S., Helm, M., Dalpke, A.H., Eigenbrod, T. (2015). 2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells. Journale of innate immunity. Mar. 20, 7(5):482-93, Full text

 

PMID: 25823462

4,4

62.

Juedes, A., Ebert, F., Baer, C., Thuering, K. L., Harrer, A., Klassen, R., Helm, M. & Schaffrath, R. (2015). Urmylation and tRNA thiolation functions of ubiquitin-like Uba4 Urm1 systems are conserved from yeast to man. FEBS letters, Mar. 03, 589(8):904-9, Full text

 

PMID: 25747390

3,2

61.

Klassen, R., Grunewald, P., Thuering, K. L., Eichler, C., Helm, M., & Schaffrath, R. (2015). Loss of Anticodon Wobble Uridine Modifications Affects tRNALys Function and Protein Levels in Saccharomyces cerevisiae. PLoS ONE, Mar 6;10(3):e0119261, Full text

 

PMID: 25747122

3,2

60.

Abdel-Fattah, W., Jablownski, D., Di Santo, R., Thuering, K.L., Scheidt, V., Hammermeister, A., Have, S. t., Helm, M., Schaffrath, R., Stark, M.J.R. (2015). ”Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast.€ Plos Gen. Jan 8. 11(1):e1004931. Full text

 

PMID: 25569479

7,5

-2014-

IF

59.

Krieg, B., Hirsch, M., Scholz, E., Nuhn, L., Tabujew, I., Bauer, H….,& Helm, M. (2014). New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes.€ Pharmaceutical Research. Oct 09, 32(6):1957-74, Full text

 

PMID: 25488263

3,4

58.

Spenkuch, F., Hinze, G., Kellner, S., Kreutz, C., Micura, R., Basché, T. & Helm, M. (2014). ”Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor.€ Nucleic Acids Research. Oct 09, 42(20):12735-45, Full text

 

PMID: 25300485

9,1

57.

Kellner, S., Ochel, A., Thüring, K., Spenkuch, F., Neumann, J., Sharma, S., Entian, K.D., Schneider, D. & Helm, M. (2014). ”Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. Nucleic Acids Research. Aug 16., 42(18):e142, Full text
.

PMID: 25129236

9,1

56.

Blanco, S., Dietmann, S., Flores, J.V., Hussain, S., Kutter, C., Humphreys, P., Lukk, M., Lombard, P., Treps, L. Popis, M., Kellner, S., Hölter, S.M., Garret, L., Wurst, W., Becker, L., Klopstock, T., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Karadottir, R.T., Helm, M., Ule, J., Gleeson, J.G., Odom, D.T., Frye, M. (2014). Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.€ The EMBO Journal, Jul 25., 33(18):2020-39, Full text
.

PMID: 25063673

10,4

55.

Kaiser, S., Rimbach, K., Eigenbrod, T., Dalpke, A.H. & Helm, M. (2014). "A modified dinucleotide motif specifies tRNA recognition by TLR7." RNA Sep. 20(9):1351-5, Full text

 

PMID: 25051971

4,9

54.

Fritz, T. Hirsch, M. Richter, F.C., Müller, S.S., Hofmann, A.M., Rusitzka, K.A., Markl, J., Massing, U., Frey, H. Helm, M. (2014). "Click modification of multifunctional liposomes bearing hyperbranched polyether chains." Biomacromolecules, Jul 14., 15(7):2440-8, Full text
.

PMID: 24805163

5,8

53.

Kotaskova M., Osman Oglou O., Helm, M. (2014) "Synthesis of new asymmetric xanthene dyes via catalyst-free SNAr with sulfur nucleophiles" Organic & Biomolecular Chemistry, Jun 21., 12(23):3816-20, Full text
.

PMID: 24802552

3,6

52.

Shanmugam, R., Aklujkar, M., Schäfer, M., Reinhardt, R., Nickel, O., Reuter, G., Lovley, D.R., Ehrenhofer-Murray, A., Nellen, W., Ankri, S., Helm, M. et al. (2014). "The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu." Nucleic Acids Research, Apr 7., 42(10):6487-96, Full text
.

PMID: 24711368

9,1

51.

Tabujew, I., Freidel, C., Krieg, B., Helm, M., Koynov, K., Müllen, K., Peneva, K. (2014). "The Guanidinium Group as a Key Part of Water-Soluble Polymer Carriers for siRNA Complexation and Protection against Degradation." Macromolecular rapid communications, Apr 4., 35(13):1191-7, Full Text
.

PMID: 24700561

4,9

50.

Buchhaupt, M., Sharma,S., Kellner, S., Oswald, S.,Paetzold, M., Pfeifer, C., Watzinger, P., Schraeder, J., Helm, M., Entian, K.D.(2014). "Partial Methylation at Am100 in 18S rRNA of Baker's Yeast Reveals Ribosome Heterogeneity on the Level of Eukaryotic rRNA Modification." PLoS One, Feb 28, 9(2):e89640, Full text
.

PMID: 24586927

3,2

49.

Kellner, S., Neumann, J., Rosenkranz, D., Lebedeva, S., Ketting, R.F., Zischler, H., Schneider, D., & Helm, M.*(2014). "Profiling of RNA modifications by multiplexed stable isotope labelling." Chemical Communications. (Cambridge, England), Apr 4., 50(26):3516-8, Full text

PMID: 24567952

6,8

-2013-

IF

48.

Kellner, S., Kollar, L. B., Ochel, A., Ghate, M. & Helm, M. (2013). "Structure-Funct
ion Relationship of Substituted Bromomethylcoumarins in Nucleoside Specificity of RNA Alkylation." PLoS One. (Public Library of science), Jul 3., 8(7):e67945, Full text

PMID: 23844135

3,2

47.

Machnicka, M. A., Milanowska, K., Osman Oglou, O., Purta, E., Kurkowska, M., Olchowik, A., Januszewski, W., Kalinowski, S., Dunin-Horkawicz, S., Rother, K., Helm, M., Bujnicki, J. M. & Grosjean, H. (2012). "MODOMICS: a database of RNA modification pathways--2012 update." Nucleic Acids Research, Oct 30, 41(Database issue):D262-7, Full text

PMID: 23118484

9,1

-2012-

IF

46.

Seidu-Larry, S., Krieg, B., Hirsch, M., Helm, M. & Domingo, O. (2012). "A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge." Chemical Communications (Cambridge, England), Nov 18., 48(89):11014-6, Full text

PMID: 23037931

6,8

45.

Tuorto, F., Liebers, R., Musch, T., Schaefer, M., Hofmann, S., Kellner, S., Frye, M., Helm, M., Stoecklin, G. & Lyko, F. (2012). "RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis." Nature Structural & Molecular Biology. Sep, 19(9):900-5, Full Text

PMID: 22885326

13,3

44.

Jurkowski, T. P., Shanmugam, R., Helm, M. & Jeltsch, A. (2012). "Mapping the tRNA Binding Site on the Surface of Human DNMT2 Methyltransferase." Biochemistry, Jun 5., 51(22):4438-44, Full text

PMID: 22591353

3,0

43.

Sencilo, A., Paulin, L., Kellner, S., Helm, M. & Roine, E. (2012). "Related haloarchaeal pleomorphic viruses contain different genome types." Nucleic Acids Research, Jul 40(12):5523-34, Full Text

PMID: 22396526

9,1

42.

Nuhn, L., Hirsch, M., Krieg, B., Koynov, K., Fischer, K., Schmidt, M., Helm, M. & Zentel, R. (2012). "Cationic Nanohydrogel Particles as Potential siRNA Carriers for Cellular Delivery." ACS Nano, Mar 27., 6(3):2198-214, Full text

PMID: 22381078

12,9

41.

Gehrig, S., Eberle, M. E., Botschen, F., Rimbach, K., Eberle, F., Eigenbrod, T., Kaiser, S., Holmes, W. M., Erdmann, V. A., Sprinzl, M., Bec, G., Keith, G., Dalpke, A. H. & Helm, M. (2012). "Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity." The Journal of Experimental Medicine, Feb 13., 209(2):225-33, Full text

PMID: 22312113

12,5

40.

Hirsch, M., Strand, D. & Helm, M. (2012). "Dye selection for live cell imaging of intact siRNA." Biological Chemistry , Jan, 393(1-2):23-3, Full text

PMID: 22628296

3,3

-2011-

39.

Kobitski, A. Y., Hengesbach, M., Seidu-Larry, S., Dammertz, K., Chow, C. S., van Aerschot
, A., Nienhaus, G. U. & Helm, M. (2011). "Single-Molecule FRET Reveals a Cooperative Effect of Two Methyl Group Modifications in the Folding of Human Mitochondrial tRNA(Lys)." Chemistry & Biology , Jul 19., 18(7):928-36, Full text

PMID: 21802013

6,7

38.

Kellner, S., Seidu-Larry, S., Burhenne, J., Motorin, Y. & Helm, M. (2011). "A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA." Nucleic Acids Research, Sep 1., 39(16):7348-60, Full text

PMID: 21646334

 

9,1

37.

Nguyen, T. H., Steinbock, L. J., Butt, H. J., Helm, M. & Berger, R. (2011). "Measuring single small molecule binding via rupture forces of a split aptamer." Journal of the American Chemical Society , Feb 23., 133(7):2025-7, Full text

PMID: 21287983

12,1

36.

Dammertz, K., Hengesbach, M., Helm, M., Nienhaus, G. U. & Kobitski, A. Y. (2011). "Single-molecule FRET studies of counterion effects on the free energy landscape of human mitochondriallysine tRNA." Biochemistry , Apr 19., 50(15):3107-15, Full text

PMID: 21375355

3,0

35.

Motorin, Y., Burhenne, J., Teimer, R., Koynov, K., Willnow, S., Weinhold, E. & Helm, M. (2011). "Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling." Nucleic Acids Research , Mar, 39(5):1943-5, Full text

PMID: 21037259


9,1

-2010-

34.

Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M. & Lyko, F. (2010). "RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage." Genes & Development , Aug 1., 24(15):1590-5, Full Text

PMID: 20679393


10,8

33.

Hengesbach, M., Voigts-Hoffmann, F., Hofmann, B. & Helm, M. (2010). "Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET." RNA, Mar, 16(3):610-2, Full Text

PMID: 20106954

4,9

32.

Tovy, A., Siman Tov, R., Gaentzsch, R., Helm, M. & Ankri, S. (2010). "A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity." PLoS Pathogens , Feb 19., 6(2):e1000775, Full text

PMID: 20174608

7,6

-2009-

31.

Fuest, C., Bankstahl, M., Winter, P., Helm, M., Pekcec, A. & Potschka, H. (2009). "In vivo down-regulation of mouse brain capillary P-glycoprotein: a preliminary investigation." Neuroscience Letters , Oct 16., 464(1):47-51, Full text

PMID: 19679165

2,0

30.

Hayrapetyan, A., Grosjean, H. & Helm, M. (2009). "Effect of a quaternary pentamine on RNA stabilization and enzymatic methylation." Biological Chemistry , Sep, 390(9):851-6, Full text

PMID: 19558320

3,3

29.

Hirsch, M., Ziroli, V., Helm, M. & Massing, U. (2009). "Preparation of small amounts of sterile siRNA-liposomes with high entrapping efficiency by dual asymmetric centrifugation (DAC)." Journal of Controlled Release , Apr 2.,135(1):80-8, Full text

PMID: 19124051

7,7

-2008-

28.

Jurkowski, T. P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G. & Jeltsch, A.  (2008). "Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism." RNA , Aug, 14(8):1663-70, Full text

PMID: 18567810


4,9

27.

Kobitski, A. Y., Hengesbach, M., Helm, M. & Nienhaus, G. U. (2008). "Sculpting an RNA conformational energy landscape by a methyl group modification--a single-molecule FRET study." Angewandte Chemie (International Ed in Englisch) 47(23):4326-30, Full text

PMID: 18449867

11,3

26.

Steinbock, L. J. & Helm, M. (2008). "Wavelength dependence of photoinduced microcantilever bending in the UV-VIS range." Sensors 8(1):23-34, Full text

doi:10.3390/s8010023

2,3

25.

Hengesbach, M., Meusburger, M., Lyko, F. & Helm, M. (2008). "Use of DNAzymes for site-specific analysis of ribonucleotide modifications." RNA , Jan, 14(1):180-7, Full text

PMID: 17998290

4,9

-2007-

24.

Voigts-Hoffmann, F., Hengesbach, M., Kobitski, A. Y., van Aerschot, A., Herdewijn, P., Nienhaus, G. U. & Helm, M. (2007). "A methyl group controls conformational equilibrium in human mitochondrial tRNA(Lys)." Journal of the American Chemical Society, Nov 7., 129(44):13382-3, Full text

PMID: 17941640

12,1

23.

Järve, A., Müller, J., Kim, I. H., Rohr, K., MacLean, C., Fricker, G., Massing, U., Eberle, F., Dalpke, A., Fischer, R., Trendelenburg, M. F. & Helm, M. (2007). "Surveillance of siRNA integrity by FRET imaging." Nucleic Acids Research, 35(18):e124, Full text 

PMID: 17890733


9,1

22.

Wehrmeister, J., Fuss, A., Saurenbach, F., Berger, R. & Helm, M. (2007). "Readout of micromechanical cantilever sensor arrays by Fabry-Perot interferometry." The Review of Scientific Instruments, Oct, 78(10):104105, Full text

PMID: 17979440

1,6

21.

Kobitski, A. Y., Nierth, A., Helm, M., Jaschke, A. & Nienhaus, G. U. (2007). "Mg2+-dependent folding of a Diels-Alderase ribozyme probed by single-molecule FRET analysis." Nucleic Acids Research, 35(6):2047-5, Full text

PMID: 17344321


9,1

-2006-

20.

Maniura-Weber, K., Helm, M., Engemann, K., Eckertz, S., Mollers, M., Schauen, M., Hayrapetyan, A., von Kleist-Retzow, J. C., Lightowlers, R. N., Bindoff, L. A. & Wiesner, R. J. (2006). "Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNALeu(UUR)) gene." Nucleic Acids Research 34(22):6404-15, Full text

PMID: 17130166

9,1

-2005-

19.

Möllers, M., Maniura-Weber, K., Kiseljakovic, E., Bust, M., Hayrapetyan, A., Jaksch, M., Helm, M., Wiesner, R. J. & von Kleist-Retzow, J. C. (2005). "A new mechanism for mtDNA pathogenesis: impairment of post-transcriptional maturation leads to severe depletion of mitochondrial tRNASer(UCN) caused by T7512C and G7497A point mutations." Nucleic Acids Research , Sep 30., 33(17):5647-58, Full text

PMID: 16199753

9,11

18.

Kurschat, W. C., Müller, J., Wombacher, R. & Helm, M. (2005). "Optimizing splinted ligation of highly structured small RNAs." RNA , Dec, 11(12):1909-14, Full text

PMID: 16251384


4,9

17.

Helm, M., Petermeier, M., Ge, B., Fiammengo, R. & Jäschke, A. (2005). "Allosterically activated Diels-Alder catalysis by a ribozyme." Journal of the American Chemical Society , Aug 3, 127(30):10492-3, Full text

PMID: 16045328

12,1

16.

Helm, M., Servant, J. J., Saurenbach, F. & Berger, R. (2005). "Read-out of micromechanical cantilever sensors by phase shifting interferometry." Applied Physics Letters 87(6).

doi:10.1063/ 1.2008358

3,3

-2004-

15.

Sissler, M., Helm, M., Frugier, M., Giege, R. & Florentz, C. (2004). "Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants." RNA, May, 10(5):841-53

PMID: 15100439


4,9

14.

Helm, M. & Attardi, G. (2004). "Nuclear control of cloverleaf structure of human mitochondrial tRNA(Lys)." Journal of Molecular Biology , Mar 26., 337(3):545-60, Full text

PMID: 15019776

3,0

13.

Asin-Cayuela, J., Helm, M. & Attardi, G. (2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity." Journal of Biological Chemistry , Apr 9., 279(15):15670-7, Full text

PMID: 14744862


4,6

-2001-

12.

Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. & Marchfelder, A. (2001). "The plant tRNA 3' processing enzyme has a broad substrate spectrum." Biochemistry , Jul 27., 40(28):8264-72, Full text

PMID: 11444972

3,0

11.

Helm, M., Kopka, M. L., Sharma, S. K., Lown, J. W. & Giege, R. (2001). "RNase activity of a DNA minor groove binder with a minimalist catalytic motif from RNase A." Biochemical and Biophysical Research Communications , Mar, 281(5):1283-90, Full text

PMID: 11243875

2,3

-2000-

10.

Helm, M., Brule, H., Friede, D., Giege, R., Putz, D. & Florentz, C. (2000). "Search for characteristic structural features of mammalian mitochondrial tRNAs." RNA , Oct, 6(10):1356-7, Full text

PMID: 11073213


4,9

-1999-

9.

Helm, M., Giege, R. & Florentz, C. (1999). "A Watson-Crick base-pair-disrupting methyl group (m1A9) is sufficient for cloverleaf folding of human mitochondrial tRNALys." Biochemistry , Oct 5., 38(40):13338-46, Full text

PMID: 10529209

3,0

8.

Vlasov, A. V., Helm, M., Naumov, V. A., Breusov, A. A., Buneva, V. N., Florentz, C., Giege, R. & Nevinskii, G. A. (1999). "[Features of tRNA hydrolysis by autoantibodies from blood serum of patients with certain autoimmune and virus diseases]." Molekuliarnaia Biologiia (Mosk) , Sep -Oct, 33(5):866-72

PMID: 10579192

  N/A

7.

Vlassov, A. V., Helm, M., Florentz, C., Naumov, V. A., Breusov, A. A., Buneva, V. N., Giege, R. & Nevinsky, G. A. (1999). "Variability of Substrate Specificity of Serum Antibodies Obtained from Patients with Different Autoimmune and Viral Diseases in Reaction of tRNA Hydrolysis." Russian Journal of Immunologie , Apr, 4(1):25-32

PMID: 12687113

  N/A

6.

Helm, M., Brule, H., Giege, R. & Florentz, C. (1999). "More mistakes by T7 RNA polymerase at the 5' ends of in vitro-transcribed RNAs." RNA , May, 5(5):618-21, Full text

PMID: 10334331


4,9

5.

Helm, M., Florentz, C., Chomyn, A. & Attardi, G. (1999). "Search for differences in post-transcriptional modification patterns of mitochondrial DNA-encoded wild-type and mutant human tRNALys and tRNALeu(UUR)." Nucleic Acids Research , Feb 1., 27(3):756-63, Full text

PMID: 9889270


9,1

-1998-

4.

Degoul, F., Brule, H., Cepanec, C., Helm, M., Marsac, C., Leroux, J., Giege, R. & Florentz, C. (1998). "Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene." Human Molecular Genetics , Mar, 7(3):347-54, Full text

PMID: 9466989


6,4

3.

Vlassov, A., Florentz, C., Helm, M., Naumov, V., Buneva, V., Nevinsky, G. & Giege, R. (1998). "Characterization and selectivity of catalytic antibodies from human serum with RNase activity." Nucleic Acids Research, Dec 1., 26(23):5243-50, Full text

PMID: 9826744


9,1

2.

Frugier, M., Helm, M., Felden, B., Giege, R. & Florentz, C. (1998). "Sequences outside recognition sets are not neutral for tRNA aminoacylation. Evidence for nonpermissive combinations of nucleotides in the acceptor stem of yeast tRNAPhe." The Journal of Biological Chemistry , May 8., 273(19):11605-10, Full text

PMID: 9565578


4,8

1.

Helm, M., Brule, H., Degoul, F., Cepanec, C., Leroux, J. P., Giege, R. & Florentz, C. (1998). "The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA." Nucleic Acids Research ,Apr 1., 26(7):1636-43, Full text

PMID: 9512533


9,1