Original Arbeiten und Reviews

* corresponding author      # shared first authorship

-Originals- -Reviews-
156. Görlitz, K., Bessler, L., Helm, M., Schaffrath, R., Klassen, R., Fluoropyrimidines trigger decay of hypomodified tRNA in yeast, (2024), Nucleic Acid Res., May, 8, Online ahead of print, Full text R26 Motorin, Y., Helm, M., General Principles and Limitations for Detection of RNA Modifications by Sequencing, (2024), Acc Chem Res., Feb. 6, 57(3):275-288, Full text
PMID: 38716877 IF: 14.9 PMID: 38065564 IF: 24.5
155. Sudol, C., Kilz, L.-M., Marchand, V., Thullier, Q., Guérineau, V., Goyenvalle, C., Faivre, B., Toubdji, S., Lombard, M., Jean-Jean, O., de Crecy-Lagard, V., Helm, M., Motorin, Y., Brégeon, D., Hamdane, D., Functional redundancy in tRNA dihydrouridylation, (2024), Nucleic Acid Res., Apr. 29, Online ahead of print, Full text
PMID: 38682613 IF: 14.9
154. Bessler, L., Sirleaf, J., Kampf, C.J., Frankowska, K., Leszczyńska, G., Opatz, T., Helm, M.*, Esterification of Cyclic N6-threonylcarbamoyladenosine during RNA Sample Preparation, (2024), Chem Med Chem., Apr. 17, Online ahead of print, Full text
PMID: 38630955 IF: 3.5
153. Bessler, L., Groß, J., Kampf, C.J., Opatz, T., Helm, M.*, Reversible oxidative dimerization of 4-thiouridines in tRNA isolates, (2024), RSC Chem Biol., Feb.1, 5(3):216-224, Full text
PMID: 38456039 IF: 4.1
152. Jörg, M., Plehn, J.E., Kristen, M., Lander, M., Walz, L., Lietz, C., Wijns, J., Pichot, F., Rojas-Charry, L., Wirtz Martin, K.M., Ruffini, N., Kreim, N., Gerber, S., Motorin, Y., Endres, K., Rossmanith, W., Methner, A., Helm, M.*, Friedland, K.*, N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer's disease, (2024), Mol. Psychiatry, Jan. 29, Online ahead of print, Full text R25 Delaunay, S., Helm, M., Frye, M, RNA modifications in physiology and disease: towards clinical applications, (2023), Nat Rev Genet., Sept. 15, 104-122,  Full text
PMID: 38287100 IF: 11.0 PMID: 37714958 IF: 59.9
-Originals- -Reviews-
151. Boulet. M., Gilbert, G., Renaud, Y., Schmidt-Dengler, M., Plantié, E., Bertrand, R., Nan, X., Jurkowski, T., Helm, M., Vandel, L., Waltzer, L., Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase, (2023), Elife, Dec., 21:12:RP91655,  Full text
PMID: 38126351 IF: 8.7
150. Cirzi, C., Dyckow, J., Legrand, C., Schott, J., Guo, W., Perez Hernandez, D., Hisaoka, M., Parlato, R., Pitzer, C., van der Hoeven, F., Dittmar, G., Helm, M., Stoecklin, G., Schirmer, L., Lyko, F., Tuorto, F., Queuosine-tRNA promotes sex-dependent learning and memory formation by maintaining codon-biased translation elongation speed, (2023), EMBO J., Aug 23, 42(19):e112507,  Full text
PMID: 37609797 IF: 11.4
149. Wierczeiko, A., Pastore S., Mündnich, S., Busch, A.M., Dietrich, V., Helm, M., Butto, T., Gerber, S., NanopoReaTA: a user-friendly tool for nanopore-seq real-time transcriptional analysis, (2023), Bioinformatics, Aug 7, 39(8):btad492,  Full text  
PMID: 37549052 IF: 6.9  
148. García-Vílchez, R., Añazco-Guenkova, A.M., Dietman, S., López, J., Morón-Calvente, V., D'Ambrosi, S., Nombela, P., Zamacola, K., Mendizabal, I., García-Longarte, S., Zabala-Letona, A., Astobiza, I., Fernández, S., Paniagua, A., Miguel-López, B., Marchand, V., Alonso-López, D., Merkel, A., García-Tuñón, I., Ugalde-Olano, A., Loizaga-Iriarte, A., Lacas-Viscasilla, I., Unda, M., Azkargota, M., Elortza, F., Bárcena, L., Gonzalez-Lopez,M., Aransay, A.M., Di Domenico, T., Sánchez-Martín, M., De Las Rivas, J., Guil, S., Motorin, Y., Helm, M., Pandolfi, P.P., Carracedo, A., Blanco, S., METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer, (2023), Mol. Cancer, Jul 29, 22(1):119,  Full text  
PMID: 37516825 IF: 41.4  
147. Koch, J., Neuberger, M., Schmidt-Dengler, M., Xu, J., Carneiro, V. C., Ellinger, J., Kriegmair, M.C., Nuhn, P., Erben, P., Michel, M.S., Helm, M., Rodríguez-Paredes, M., Nientiedt, M., Lyko, F., Reinvestigating the clinical relevance of the m6A writer METTL3 in urothelial carcinoma of the bladder, (2023), iScience, Jul 11, 26(8):107300,  Full text  
PMID: 37554463 IF: 6.1  
146. Schwickert, M., Zimmermann, R. A., Habeck, T., Hoba, S. N., Nidoieva, Z., Fischer, T. R., Stark, M. M., Kersten, C., Lermyte, F., Helm, M.*, Schirmeister, T.*, Covalent S-Adenosylhomocysteine-Based DNA Methyltransferase 2 Inhibitors with a New Type of Aryl Warhead, (2023), ACS Med Chem Lett., May 9, 14(6):777-787,  Full text  
PMID: 37312859 IF: 4.6  
145. Bessler, L., Vogt, L. M., Lander, M., Dal Magro, C., Keller, P., Kühlborn, J., Kampf, C. J., Opatz, T., & Helm, M.*  A New Bacterial Adenosine-Derived Nucleoside as an Example of RNA Modification Damage, (2023), Angewandte Chemie (International ed. in English),      Mar 6;62(11):e202217128,  Full text  
PMID: 36629490 IF:15.3  
144. Koshla, O., Vogt, L. M., Rydkin, O., Sehin, Y., Ostash, I., Helm, M., & Ostash, B. Landscape of Post-Transcriptional tRNA Modifications in Streptomyces albidoflavus J1074 as Portrayed by Mass Spectrometry and Genomic Data Mining, (2022), Journal of bacteriology, Epub 2022 Dec 5, J Bacteriol. 2023 Jan 26;205(1):e0029422   Full text  
PMID: 36468867 IF: 3.5  
-Originals- -Reviews-
143. Pichot, F., Hogg, M. C., Marchand, V., Bourguignon, V., Jirström, E., Farrell, C., Gibriel, H. A., Prehn, J. H. M., Motorin, Y.*, & Helm, M.*,  Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines, (2022), Computational and structural biotechnology journal21, Dec 19, 21:401-417, Full text R24 Brégeon,D., Pecqueur, L., Toubdji, S., Sudol, C., Lombard, M., Fontecave, M., de Crécy-Lagard, V., Motorin, Y., Helm, M., Hamdane, D., Dihydrouridine in the Transcriptome: New Life for This Ancient RNA Chemical Modification, (2022), ACS Chem Biol., Jun. 23Full text
PMID: 36618980 IF:7.3 PMID: 35737906 IF:4.4
142. Zimmermann, R. A., Schwickert, M., Meidner, J. L., Nidoieva, Z., Helm, M.*, & Schirmeister, T.*, An Optimized Microscale Thermophoresis Method for High-Throughput Screening of DNA Methyltransferase 2 Ligands, (2022), ACS pharmacology & translational science, Oct. 19., 5(11):1079-1085 R23 Helm, M., Motorin, Y., Phosphorylation found inside RNA, (2022), Nature, May, 605(7909):234-235, Full text
PMID: 36407957  IF: 4.9 PMID: 35478019 IF: 42.8
141. Bessler, L.#, Kaur, N.#, Vogt, L.-M.#, Flemmich, L., Siebenaller, C., Winz, M.-L., Tuorto, F., Micura, R., Ehrenhofer-Murray, A.E.*,  Helm, M.*, Functional integration of a semi-synthetic azido-queuosine derivative into translation and a tRNA modification circuit, (2022), Nucleic Acids Res., Sep. 28, 50(18):10785-10800, Full text R22 Fischer TR, Meidner L, Schwickert M, Weber M, Zimmermann RA, Kersten C, Schirmeister T, Helm M., Chemical biology and medicinal chemistry of RNA methyltransferases, (2022), Nucleic Acid Res., Apr. 22, 50(8):4216-4245, Full text
PMID: 36169220 IF: 19.2 PMID: 35412633  IF: 19.2
140. Ravichandran, M., Rafalski, D., Davies, C.I., Ortega-Recalde, O., Nan, X., Glanfield, C.R., Kotter, A., Misztal, K., Wang, A.H., Wojciechowski, M., Rażew, M., Mayyas, I.M., Kardailsky, O., Schwartz, U., Zembrzycki, K., Morison, I.M., Helm, M., Weichehan, D., Jurkowska, Krueger, F., Plass, C., Zacharias, M., Bochtler, M., Hore, T.A., Jurkowski, T.P., Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function, (2022), Sci Adv., Sep. 9, 8(36):eabm2427, Full text
PMID: 36070377 IF: 14.1
139. Hertler, J.#, Slama, K.#, Schober, B., Özrendeci, Z., Marchand, V., Motorin, Y., Helm, M.*, T.P., Synthesis of point-modified mRNA., (2022), Nucleic Acid Res., Sep. 5, 50(20):e115, Full text
PMID: 36062567 IF: 19.2
138. Henry, B.A., Marchand, V., Schlegel, B.T., Helm, M., Motorin, Y., Lee, N., Pseudouridylation of Epstein-Barr Virus Noncoding RNA EBER2 Facilitates Lytic Replication, (2022), RNA, Sep. 13, 28(11):1542-1552, Full text
PMID: 36100352 IF: 4.9
137. Cavallin, I., Bartosovic, M., Skalicky, T., Rengaraj, P., Demko, M., Schmidt-Dengler, M.C., Drino, A., Helm, M., Vanacova, S., HITS-CLIP analysis of human ALKBH8 reveals interactions with fully processed substrate tRNAs and with specific noncoding RNAs, (2022), RNA, Oct. 3, 28(12):1568-1581, Full text
PMID: 36192131 IF: 4.9
136. Kallert, E., Fischer, T.R., Schneider, S., Grimm, M., Helm, M., Kersten, C., Protein-Based Virtual Screening Tools Applied for RNA-Ligand Docking Identify New Binders of the preQ1-Riboswitch, (2022), J Chem. Inf. Model, Sep. 12, 62(17):4134-4148, Full text
PMID: 35994617 IF: 6.2
135. Schwickert, M., Fischer, T.R., Zimmermann, R.A., Hoba, S.N., Meidner, J.L., Weber, M., Weber, M., Stark, M.M., Koch, J., Jung, N., Kersten, C., Windbergs, M., Lyko, F., Helm, M.*, Schirmeister, T.*, Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment, (2022), J Med Chem., Jul. 18, 65(14):9750-9788, Full text
PMID: 35849534 IF: 6.3
134. Pichot, F., Marchand V., Helm, M., Motorin Y., Machine learning algorithm for precise prediction of 2'-O-methylation (Nm) sites from experimental RiboMethSeq datasets, (2022), Methods., Jul, 203:311-321, Full text
PMID: 35314341 IF: 4.7
133. Richter, F.#, Plehn. J.E.#, Bessler, L., Hertler, J., Jörg, M., Cirzi, C., Tuorto, F., Friedland, K.*, Helm, M.*, RNA marker modifications reveal the necessity for rigorous preparation protocols to avoid artifacts in epitranscriptomic analysis, (2022), Nucleic Acid Res., May 6, 50(8):4201-4215, Full text
PMID: 34850949 IF: 19.2
132. Barthels, F., Hammerschmidt, S.J., Fischer, T.R., Zimmer, C., Kallert, E., Helm, M., Kersten, C., Schirmeister, T., A low-cost 3D-printable differential scanning fluorometer for protein and RNA melting experiments, (2022), HardwareX, Apr., Full text
DOI: https://doi.org/10.1016/j.ohx.2022.e00256 
131. Biedenbänder, T., de Jesus, V., Schmidt-Dengler, M., Helm, M., Corzilius, B., Fürtig, B., RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics, (2022), Nucleic Acid Res., Feb. 28, 50(4):2334-2349, Full text
PMID: 35137185 IF: 19.2
-Originals- -Reviews-
130. Schöller, E., Marks, J., Marchand, V., Bruckmann, A., Powell, C.A., Reichold, M., Mutti, C.D., Dettmer, K., Feederle, R., Hüttelmaier, S., Helm, M., Oefner, P., Minczuk, M., Motorin, Y., Hafner, M., Meister, G., Balancing of mitochondrial translation trough METTL8-mediated m3 C modification of mitochondrial tRNAs, (2021), Mol Cell., Nov. 12, 81(23:4810-4825, Full text R21 Motorin, Y., Helm, M., RNA nucleotide methylation: 2021 update, (2021), Wiley Interdiscip Rev RNA, Dec. 15, e1691, Full text
PMID: 34774131 IF: 17,9 PMID: 34913259 IF: 11,9
129. Fradejas-Villar, N., Bohleber, S., Zhao, W., Reuter, U., Kotter, A., Helm, M., Knoll, R., McFarland, R., Taylor, R.W., Mo, Y., Miyauchi, K., Sakaguchi, Y., Suzuki, T., Schweizer, U., The Effect of tRNA [Ser]Sec Isopentenylation on Selenoprotein Expression, (2021), Molecular Sciences, Oct. 23, 22(21) 11454, Full text R20 Fagan, S.G., Helm, M., Prehn, J.H.M., tRNA-derived fragments: A new class of non-coding RNA with key roles in nervous system function and dysfunction, (2021), Prog. Neurobiol., Oct., 205:102118, Full text
PMID: 34768885 IF: 5,9 PMID: 34245849 IF: 11
128. Johann, K., Bohn, T., Shahneh, F., Luther, N., Birke, A., Jaurich, H., Helm, M., Klein, M., Raker, V.K., Bopp, T., Barz, M., Becker, C., Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression, (2021), Nat. Commun., Oct. 13, 12(1):5981, Full text R19 Helm, M., Schmidt-Dengler, M.C., Weber, M., Motorin, Y., General Principles for the Detection of Modified Nucleotides in RNA by Specific Reagents, (2021), Adv. Biol. (Weinh), Sep. 17, 5(10):e2100866
PMID:34645812 IF: 12,1 PMID: 34535986 IF: 3,5
127. Schmidt, J., Goergens, J., Pochechueva, T., Kotter, A., Schwenzer, N., Sitte, M., Wener, G., Altmüller, J., Thiele, H., Nürnberg, P., Isensee, J., Li, Y., Müller, C., Leube, B., Reinhardt, H.C., Hucho, T., Salinas, G., Helm, M., Jachimowicz, R.D., Wieczorek, D., Kohl, T., Lehnhart, S. E., Yigit, G., Wollnik, B., Biallelic variants in YRDC cause a developmental disorder with progeroid features, (2021), Hum Genet., Sep. 20, 140(12):1679-1693, Full text
PMID: 34545459 IF: 5,7
126. Bawankar, P., Lence, T., Paolantoni, C., Haussmann, I.U., Kazlauskiene, M., Jacob, D., Heidelberger, J.B., Richter, F.M., Nallasivan, M.P., Morin, V., Kreim, N., Beli, P., Helm, M., Jinek, M., Soller, M., Roignant, J.-Y., Hakai is required for stabilization of core components of the m6A mRNA methylation machinery, (2021), Nat Commun., Jun. 18, 12(1):3778, Full text
PMID: 34145251 IF: 12,1
125. Siebenaller, C., Schlösser, L., Junglas, B., Schmidt-Dengler, M., Jacob, D., Hellmann, N., Sachse, C., Helm, M., Schneider, D., Binding and/or hydrolysis of purine-based  nucleotides is not required for IM30 ring information, (2021), FEBS Lett., Jun. 1, 595(14):1876-1885, Full text
PMID: 34060653 IF: 3,1
124. Duda, K.J., Ching, W.R., Jerabek, L., Shukeir, N., Erikson, G., Engist, B., Onishi-Seebacher, M., Perrera, V., Richter, F., Mittler, G., Fritz, K., Helm, M., Knuckles, P., Bühler, M., Jenuwein, T., m6A RNA methylation of major satellite repeat transcripts facilitates chromatin association and RNA: DNA hybrid formation in mouse heterochromatin, (2021), Nucleic Acid Res., May 17, 49(10):5568-5587, Full text
PMID: 33999208 IF: 16,9
123. Coll-SanMartin, L., Davalos, V., Piñeyro, D., Rosselló-Tortella, M., Bueno-Costa, A., Setien, F., Villanueva, A., Granada, I., Ruiz-Xiviller, N., Kotter, A., Helm, M., Yokota, J., Kawabata-Iwakawa, R., Kohno, T., Esteller, M., Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensivitiy to Arsenic Trioxide in Small-Cell Lung Cancer, (2021), Cancers, Apr. 14, 13(8):1869, Full text
PMID: 33919717 IF: 6,1
122. Cunha Navarro, I., Tuorto, F., Jordan, D., Legrand, C., Price, J., Braukmann, F., Hendrik, A.G. Akay, A., Kotter, A., Helm, M., Lyko, F., Miska, E.A., Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans, (2021), EMBO J., Mar. 15, e105496, Full text
PMID: 33283887 IF: 9,9
121. Werner, S.#, Galliot, A.#, Pichot, F., Kemmer, T., Marchand, V., Sednev, M.V., Lence, T., Roignant, J.-Y., König, J., Höbartner, C., Motorin, Y., Hildebrandt, A., Helm, M.*, NOseq: amplicon sequencing evaluation method for RNA m6A sites after chemical deamination, (2021), Nucleic Acids Res., Feb. 26, 49(4):e23, Full text
PMID: 33313868 IF: 16,9
120. Schupp, J., Christians, A., Zimmer, N., Gleue, L., Jonuleit, H., Helm, M., Tuettenberg, A., In-Depth Immune-Onclogy Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model, (2021), Int J Mol Sci., Jan. 20, 22(3):1011, Full text
PMID: 33498319 IF: 4,6
119. Pichot, F., Marchand, V., Helm, M., Motorin, Y., Non-Redundant tRNA References Sequences for Deep Sequencing Analysis of tRNA Abundance and Epitranscriptomic RNA Modifications, (2021), Genes, Jan. 10, 12(1):81, Full text
PMID: 33435213 IF: 3,6
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118. Galvanin, A., Vogt, L.-M., Grober, A., Freund, I., Ayadi, L., Bourguignon-Igel, V., Bessler, L., Jacob, D., Eigenbrod, T., Marchand, V., Dalpke, A., Helm, M., Motorin, Y., Bacterial tRNA 2'-O-metyhlation is dynamically regulated under stress conditions and modulates innate immune response, (2020), Nucleic Acids Res., Dec. 16, 48(22):12833-12844, Full text R18 Ruggieri, A., Helm, M., Chatel-Chaix, L., An epigenetic "extreme makeover": the methylation of flaviviral RNA (and beyond), (2020), RNA Biol.,  Epub Dec. 23; Print 2021 May;18(5):696-708., Full text
PMID: 33275131 IF: 11,5 PMID: 33356825 IF: 5,4
117. Gleue, L., Schupp, J., Zimmer, N., Becker, E., Frey, H., Tuettenberg, A.*, Helm, M.,*, Stability of Alkyl Chain-Mediated Lipid Anchoring in Liposomal Membranes, (2020), Cells., Sep. 29, 9(10):2213, Full text
PMID: 33003620 IF: 4,4
116. Marchand, V., Pichot, F., Neybecker, P., Ayadi, L., Bourguignon-Igel, V., Wacheul, L., Lafontaine, D.L.J., Pinzano, A., Helm, M., Motorin, Y., HydraPsiSeq: a method for systematic and quantitative mapping of pseudouridines in RNA, (2020), Nucleic Acid Res., Sep. 25, 48(19):e10, Full text
PMID: 32976574 IF: 11.5
115. Kristen, M., Plehn, J., Marchand, V., Friedland, K., Motorin, Y., Helm, M., Werner, S.*, Manganese Ions Individually Alter the Reverse Transcription Signature of Modified Ribonucleosides., (2020), Genes (Basel), Aug. 18, 11(8):950, Full text
PMID: 32824672 IF: 3.8
114. Weichmann, F., Hett, R., Schepers, A., Ito-Kureha, T., Flatley, A., Slama, K., Hastert, F., Angstmann, N., Cardoso, C.M., König, J., Huettelmaier, S., Dieterich, C., Canzar, S. Helm, M., Heissmeyer, V., Feederle, R., Meister, G., Validation strategies for antibodies targeting modified ribonucleotides., (2020), RNA, Jul. 7, 26(10):1489-1506, Full text
PMID: 32636310 IF: 5.5
113. Vilardo, E., Amman, F., Toth, U., Kotter, A., Helm, M., Rossmanith, W., Functional Characterization of the Human tRNA Methyltransferases TRMT10A and TRMT10B., (2020), Nucleic Acids Res., Jun. 19, 48(11):6157-6169, Full text
PMID: 32392304 IF: 11,5
112. Henry, B.A., Kanarek, J.P., Kotter, A., Helm, M., Lee, N., 5-Methylcytosine Modification of an Epstein-Barr Virus Decreases its Stability., (2020), RNA, Apr. 30, 26(8):1038-1048, Full text
PMID: 32354721 IF: 5,5
111. Werner, S.#, Schmidt, L.#, Marchand, V., Kemmer, T., Falschlunger, C., Sednev, M.V., Bec, G., Ennifar, E., Höbartner, C., Micura, R., Motorin, Y., Hildebrandt A.*, Helm, M.*, Machine Learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes, (2020), Nucleic Acids Res., Feb. 25, 48(7):3734-3746, Full text
PMID: 32095818 IF: 11,2
110. Meyer, B., Immer, C., Kaiser, S., Sharma, S., Yang, J., Watzinger, P., Weiß, L., Kotter, A., Helm, M., Seitz, H.M., Kötter, P., Kellner, S., Entian, K.D., Wöhnert, J., Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs., (2020), Nucleic Acids Res., Febr. 20, 48(3):1435-1450, Full text
PMID: 31863583 IF: 11,2
109. Pichot, F., Marchand, V., Ayadi, L., Bourguignon-Igel, V., Helm, M., Motorin, Y., Holistic Optimization of Bioinformatic Analysis Pipeline for Detection and Quantification of 2'-O-Methylations in RNA by RiboMethSeq., (2020), Front Genet., Feb. 13, 11:38, Full text
PMID: 32117451 IF: 3,8
-Originals- -Reviews-

Pannwitt, S., Slama, K., Depoix, F., Helm, M., Schneider, D., Against Expectations: Unassisted RNA Adsorption onto Negatively Charged Lipid Bilayers., (2019), Langmuir, Nov. 12, 35(45):14704-14711, Full text


R17 Helm, M., Lyko, F., Motorin, Y., Limited antibody specificity compromises epitranscriptomic analyses, (2019), Nat. Commun., Dec. 11, 10(1):5669, Full text
PMID: 31626734 IF: 3,7 PMID: 31827101 IF: 12,4
107. Tabujew, I., Heidari, M., Freidel, C., Helm, M., Tebbe, L., Wolfrum, U., Nagel-Wolfrum, K., Koynov, K., Biehl, P., Schacher, F.H., Potestio, R., Peneva, K., Tackling the Limitations of Copolymeric Small Interfering RNA Delivery Agents by a Combined Experimenta-Computational Approach, (2019), Biomacromolecules, Nov. 4, 20(12):4389-4406, Full text R16 Freund, I., Eigenbrod, T., Helm, M., Dalpke, A.H., RNA Modifications Modulate Activation of Innate Toll-Like Receptors., (2019)Genes (Basel), Jan. 29, 10(2), Full text
PMID: 31686497 IF: 5,7 PMID: 30699960 IF: 3,2
106. Tabujew, I., Willig, M., Leber, N., Freidel, C., Negwer, I., Koynov, K., Helm, M., Landfester, K., Zentel, R., Peneva, K., Mailänder, V., Overcoming the barrier of CD8+T cells: Two types of nano-sized carriers for siRNA transport., (2019), Acta Biomater., Oct. 04, 100:338-351, Full text R15 Motorin, Y., Helm, M., Methods for RNA Modification Mapping Using Deep Sequencing: Established and New Emerging Technologies, (2019), Genes (Basel), Jan. 9,10(1), Full text
PMID: 31586726 IF: 6,4 PMID: 30634534 IF: 3,2
105. Schmidt, L.#, Werner, S.#, Kemmer, T., Niebler, S., Kristen, M., Ayadi, L., Johe, P., Marachand, V., Schirmeister, T., Motorin, Y., Hildebrandt, A.*, Schmidt, B,*. Helm, M.*, Graphical Workflow System for Modification Calling by Machine Learning of Reverse Transcription Signatures., (2019), Front Genet., Sep. 25, 10:876, Full text
PMID: 31608115 IF: 4,2
104. Weber, C., Voigt, M., Simon, J., Danner, A.K., Frey, H., Mailänder, V., Helm, M., Morsbach, S., Landfester, K., Functionalization of Liposomes with Hydrophilic Polymers Results in Macrophage Uptake Independent of the Protein Corona., (2019), Biomacromolecules., Aug. 12, 20(8):2989-2999, Full text
PMID: 31268685 IF: 5,7
103. Carter, J.M., Emmett, W., Mozos, I.R., Kotter, A., Helm, M., Ule, J., Hussain, S., 'FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA, (2019), Nucleic Acid Res., Jul. 30, 47(19):e113, Full text
PMID: 31361898 IF: 10,2
102. Kaiser, R. W. J., Ignarski, M., Van Nostrand, E. L., Frese, C.K., Jain, M., Cukoski, S., Heinen, H., Schaechter, M., Seufert, L., Bunte, K., Frommolt, P., Keller, P., Helm, M., Bohl, K., Höhne, M., Schermer, B., Benzing, T., Höpker, K., Dieterich, C., Yeo, G. W., Müller, R. U., Fabretti, F., A protein-RNA interaction atlas of the ribosome biogenesis factor AATF, (2019)Sci. Rep., Jul. 30, 9(1):11071, Full text
PMID: 31363146  IF: 4,1
101. Freund, I., Buhl, D.K., Boutin, S., Kotter, A., Pichot, F., Marchand, V., Vierbuchen, T., Heine, H., Motorin, Y., Helm, M., Dalpke, A.H., Eigenbrod, T., 2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms, (2019), RNA., Apr. 24, 25(7):869-880, Full text
PMID: 31019095 IF: 3,6
100. Krutyholowa, R., Hammermeister, A., Zabel, R., Abdel-Fattah, W., Reinhardt-Tews, A., Helm, M., Stark, M.J.R., Breunig, K.D., Schaffrath, R., Glatt, S.,Kti12, a PSTK-like tRNA dependent A TPase essential for tRNA modification by Elongator, (2019), Nucleic Acids Rs., Mar. 27, 47(9):4814-4830, Full text
PMID: 30916349 IF: 10,6
99. Jacob, D., Thüring, K., Galliot, A., Marchand, V., Galvanin, A., Ciftci, A., Scharmann, K., Stock, M., Roignant, J.Y., Leidel, S.A., Motorin, Y., Schaffrath,R., Klassen, R., Helm. M., Absolute quantification of noncoding RNA by microscale thermophoresis, (2019), Angew. Chem. Int. Ed. Engl., Mar. 20, 58(28):9565-9569, Full text
PMID: 30892798  IF: 12,1
98. Neukranz, Y., Kotter, A., Beilschmidt, L., Marelja, Z., Helm, M., Gräf, R., Leimkühler, S., Analysis of the cellular roles of MOCS3 identifies a MOCS3-independent localization of NFS1 at the tips of the centrosome., (2019), Biochemistry, Feb. 28, 58(13):1786-1798, Full text
PMID: 30817134  IF: 3,0
97. Fricker, R., Brogli, R., Luidalepp, H., Wyss, L., Fasnacht, M., Joss, O., Zywicki, M., Helm, M., Schneider, A., Cristodero, M., Polacek, N., A tRNA half modulates  translation as stress response in Trypanosoma, (2019), Nature communications, Jan. 10, 10(1):118, Full text
PMID: 30631057  IF: 12,4
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96. Marchand, V., Ayadi, L., Ernst, F.G.M, Hertler, J., Bourguignon-Igel.V., Galvanin, A., Kotter, A., Helm, M., Lafontaine, D.L.J., Motorin, Y., AlkAniline-Seq: Profiling of m7 G and m3 C RNA Modifications at Single Nucleotide Resolution., (2018), Angew. Chem. Int. Ed. Engl., Dec. 17, 57(51):16785-16790, Full text
PMID: 30370969 IF: 12,2
95. Negwer, I., Best, A., Schinnerer, M., Schäfer, O., Capeloa, L., Wagner, M., Schmidt, M., Mailänder, V., Helm, M., Barz, M., Butt, H.J., Koynov, K., Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy, (2018), Nat. Commun., Dec. 13, 9(1):5306, Full text
PMID: 30546066 IF: 12,4
94. Keller, P., Freund, I., Marchand, V., Bec, G., Huang, R., Motorin, Y., Eigenbrod, T., Dalpke, A., Helm, M.,
Double methylation of tRNA-U54 to 2'-O-methylthymidine (TM) synergistically decreases immune response by Toll-like receptor 7., (2018), Nucleic Acids Res., Okt. 12, 46(18):9764-9775, Full text
PMID: 30102387 IF: 11,6
93. Dal Magro, C., Keller, P., Kotter, A., Werner, S., Duarte, V., Marchand, V., Ignarski, M., Freiwald, A., Müller, R.U., Dietrich, C., Motorin, Y., Butter, F., Atta, M., Helm, M.,
A vastly increased chemical variety of RNA modifications that includes a thioacetal structure, (2018), Angew. Chem. Int. Ed. Engl., Apr. 6, 57(26):7893-7897, Full text
PMID: 29624844 IF: 12
92. Knuckles, P., Lence, T., Haussmann, I. U., Jacob, D., Kreim, N., Carl, S.H., Masiello, I., Hares, T., Villaseñor, R., Hess, D., Andrade-Navarro, M.A., Biggiogera, M., Helm, M., Soller, M., Bühler, M., Roignant, J.Y.,
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d., (2018), Genes Dev., Mar. 13, 32 (5-6):415-429, Full text
PMID: 29535189 IF: 9,4
91. Aschenbrenner, J., Werner, S., Marchand, V., Adam, M., Motorin , Y., Helm, M., Marx, A., Engineering of a DNA polymerase for direct m6A Sequencing, (2018), Angew. Chem. Int. Ed. Engl., Jan. 8, 57,417-421. Full Text
PMID: 29115744 IF: 12
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90. Boccaletto, P., Machnicka, M.A., Purta, E., Piatkowski, P., Baginski, B., Wirecki, T.K., de Crécy-Lagard, V., Ross, R., Limbach, P.A., Kotter, A., Helm, M., Bujnicki, J.M., MODOMICS: a database of RNA modification Pathways. 2017 update., (2017), Nucleic Acid Research., Nov. 2, 46(D1):D303-D307, Full Text R14 Helm, M., Motorin, Y.,Detecting RNA modifications in the epitranscriptome: predict and validate, (2017), Nature Reviews Genetics, Feb. 20,18(5):275-291, Full text
PMID: 29106616  IF: 10,2 PMID: 28216634 IF: 41,5
89. Negwer, I., Hirsch, M., Kaloyanova, S., Brown, T., Peneva, K., Butt, H.J., Koynov, K., Helm, M., Modulation of Mitochondriotropic Properties of Cyanine Dyes by in Organello Copper-Free Click Reaction., (2017), Chembiochem., Sep. 19, 18(18):1814-1818, Full Text
PMID: 28704573  IF: 2,8
88. Weber, B., Kappel, C., Scherer, M., Helm, M., Bros. M., Grabbe, S., Barz, M., PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes., (2017), Macromol Biosci., Jul. 31, 17(10), Full Text
PMID: 28759159  IF: 3,3
87. Legrand, C., Tuorto, F., Hartmann, M., Liebers, R., Jacob, D., Helm, M., Lyko, F., Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs, (2017), Genome Res., Jul. 6, 27(9):1589-1596, Full text
PMID: 28684555  IF: 11,9
86. Schmitt, F.C.F., Freund, I., Weigand, M.A., Helm, M., Dalpke, A.H., Eigenbrod, T., Identification of an optimized 2'-O-methylated tri-nucleotide RNA motif inhibiting Toll-like receptor 7 and 8, (2017), RNA, Jun. 2, 23(9):1344-1351, Full text
PMID: 28576825 IF: 4,6
85. Hellmuth, I., Freund, I., Schlöder, J., Seidu-Larry, S., Thüring, K., Slama, K., Langhanki, J., Kaloyanova, S., Eigenbrod, T., Krumb, M., Röhm, S., Peneva K., Opatz, T., Jonuleit, H., Dalpke, A.H., Helm, M., Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor, (2017), 7. Fronti. Immunol., Mar. 24, 8:312, Full text
DOI: 10.3389/fimmu.2017.00312 IF: 5,7
84. Schmid, K., Adobes-Vidal, M., Helm, M., Alkyne-Functionalized Coumarin Compound for Analytic and Preparative 4-Thiouridine Labeling, (2017), Bioconjugate Chemistry, Mar. 15, 28(4):1123-1134, Full text
PMID: 28263563 IF: 4,5
83. Marchand, V., Pichot, F., Thüring, K., Avadi, L., Freund, I., Dalpke, A., Helm, M., Motorin, Y., Next-Generation Sequencing-Based RiboMethSeq Protocol for Analysis of tRNA 2'-O-Methylation, (2017), Biomolecules, Feb. 9, 7(1), Full Text
PMID: 28208788 IF: 5,8
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82. Lence, T., Akhtar, J., Bayer, M., Schmid, K., Spindler, K., Ho, CH., Kreim, N., Andrade-Navarro, MA., Poeck, B., Helm, M., Roignant, JY., m6A modulates neuronal functions and sex determination in Drosophila, (2016), Nature, Dec. 8, 540(7632):242-247, Full text R13 Motorin, Y., Seidu-Larry, S., Helm, M., (2016) DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position. Adv Exp Med Biol., 945:19-33. Full text
PMID: 27919077 IF: 38,2 PMID: 27826833 IF: 1,9
81. Kaiser, S., Jurkowski, TP., Kellner, S., Schneider, D., Jeltsch, A., Helm, M., The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA, (2016)RNA Biology, Nov., 7:1-11, Full text R12 Jeltsch, A., Ehrenhofer-Murray, A., Jurkowski, TP., Lyko, F., Reuter, G., Ankri, S., Nellen, W., Schaefer, M., Helm, M. Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation, (2016) RNA Biology., Sep. 2, 14(9):1108-1123, Full Text
PMID: 27819523 IF: 4,1 PMID: 27232191 IF: 5,2
80. Hauenschild, R., Werner, S., Tserovski, L., Hildebrandt, A., Motorin, Y., Helm, M., CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles, (2016), Biomolecues., Nov. 10, 6(4), Full text
PMID: 27834909 IF: 5,8
79. Falckenhayn, C., Carneiro, VC., de Mendonça Amarante, A., Schmid, K., Hanna, K., Kang, S., Helm, M., Dimopoulos, G., Fantappié, MR., Lyko, F., Comprehensive DNA methylation analysis of the Aedes aegypti genome, (2016) Sci. Rep., Nov. 2, 6:36444, Full text
PMID: 27805064 IF: 5,2
78. Jüdes, A., Bruch, A., Klassen, R., Helm, M., Schaffrath, R., Sulfur transfer and activation by ubiquitin-like modifier system Uba4Urm1 link protein urmylation and tRNA thiolation in yeast, (2016), Microb Cell., Oct. 24, 3(11):554-564, Full text
PMID: 28357324   IF: N/A
77. Müller, S., Fritz, T., Gimnich, M., Worm, M., Helm, M., Frey, H., Biodegradable Hyperbranched Polyether-Lipids with In-Chain pH-Sensitive Linkages, (2016) Polym. Chem., Sep. 19, Full text
DOI: 10.1039/C6PY01308B   IF: 5,7
76. Tserovski, L., Helm, M.,Diastereoselectivity of 5-methyluridine osmylation is inverted inside an RNA chain., (2016)Bioconjugate Chemistry, Aug. 19, 27(9):2188-97, Full text
PMID: 27540864   IF: 4,5
75. Fritz, T., Voigt, M., Worm, M., Negwer, I., Müller, SS., Kettenbach, K., Ross, TL., Roesch, F., Koynov, K., Frey, H., Helm, M., Orthogonal Click Conjugation to the Liposomal Surface Reveals the Stability of the Lipid Anchorage as Crucial for Targeting., (2016)Chemistry, Aug. 8, 22(33):11578-82
PMID: 27403892  IF: 5,8
74. Nick, TA., de Oliverira, TE., Pilat, DW., Spenkuch, F., Butt, HJ., Helm, M., Netz, PA., Berger, R., Stability of a Split Streptomycin Binding Aptamer., (2016)The Journal of physical chemistry. B., Jul. 14, 120(27):6479-89 , Full text
PMID: 27281393   IF: 3,2
73. Marchand, V., Blanloeil- Oillo, F., Helm, M., Motorin, Y., Illumina-based RiboMethSeq approach for mapping of 2'-O-Me residues in RNA., (2016)Nucleic Acid Research, Jun. 14, 44(16):e135, Full text
PMID: 27302133  IF: 9,1
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72. Kienhöfer, S., Musheev, MU., Stapf, U., Helm, M., Schomacher, L., Niehrs, C., Schäfer, A., (2015) GADD45a physically and functionally interacts with TET1. Differentiation, Nov. 03, 90(1-3):59-68, Full text
PMID: 26546041    IF: 3,4
71. Vogt, G., Falckenhayn, C., Schrimpf, A., Schmid, K., Hanna, K., Pantelein, J., Helm, M., Schulz, R., Lyko, F., (2015) The marbled crayfish as a paradigm for saltational speciation by autopolyploidy and parthenogenesis in animals. Biology Open, Oct. 30, 4(11):1583-94, Full Text
PMID: 26519519    IF: 2,4
70. Müller, M., Hartmann, M., Schuster, I., Bender, S., Thüring, KL., Helm, M., Katze, JR., Nellen, W., Lyko, F., Ehrenhofer-Murray, AE. (2015) Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine.Nucleic Acids Research, Sep. 30, 43(22):10952-62, Fulltext
PMID: 26424849    IF: 9,1
69. Hauenschild, R., Tserovski, L., Schmid, K., Thüring, K., Winz, ML., Sharma, S., Entian, KD., Wacheul, L., Lafontaine, DL., Anderson, J., Alfonzo, J., Hildebrandt, A., Jäschke, A., Motorin, Y., Helm, M., (2015) The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent.Nucleic Acids Research, Sep. 13, 43(20):9950-64, Fulltext
PMID: 26365242   IF: 9,1
68. Schmid, K., Thüring, K., Keller, P., Ochel, A., Kellner, S., Helm, M., (2015) Variable presence of 5-methylcytosine in commercial RNA and DNA.RNA Biology, Aug. 14, 12(10):1152-8, Full text
PMID: 26274337    IF: 5,0
67. Bourgeois, G., Ney, M., Gaspar, I., Aiqueperse, C., Schaefer, M., Kellner, S., Helm, M., Motorin, Y. (2015) Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120. PLoS One, Jul. 21, 10(7):e0133321, Fulltext
PMID: 26196125    IF: 3,2
66. Shanmugam, R., Fierer, J., Kaiser, S., Helm, M., Jurkowski, T. P., Jeltsch, A. (2015) Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences.CellDiscovery, Jun. 9, 1, 15010, Fulltext
doi:10.1038/celldisc.2015.10   IF:N/A
65. Domingo,O., Hellmuth, I., Jaeschke, A., Kreutz, C., Helm, M. (2015) Intermolecular 'cross-torque': the N4-cytosine propargyl residue is rotated to the 'CH'-edge as a result of Watson-Crick interaction. NucleicAcids Research, Apr. 30, 43(11):5275-83, Full text
PMID: 25934805    IF:9,1
64. Hirsch, M. & Helm, M. (2015) Live cell imaging of duplex siRNA intracellular trafficking. NucleicAcids Research, Apr. 13, 43(9):4650-60, Full text
PMID: 25870407    IF:9,1
63. Rimbach, K., Kaiser, S., Helm, M., Dalpke, A.H., Eigenbrod, T. (2015).2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells.Journale of innate immunity. Mar. 20, 7(5):482-93, Fulltext
PMID: 25823462    IF:4,4
62. Juedes, A., Ebert, F., Baer, C., Thuering, K. L., Harrer, A., Klassen, R., Helm, M. & Schaffrath, R. (2015).Urmylationand tRNAthiolation functions of ubiquitin-like Uba4 Urm1 systems are conserved from yeast to man. FEBS letters, Mar. 03, 589(8):904-9, Full text
PMID:25747390    IF:9,1
61. Klassen, R., Grunewald, P., Thuering, K. L., Eichler, C., Helm, M., & Schaffrath, R. (2015).Loss of Anticodon Wobble Uridine Modifications Affects tRNALys Function and Protein Levels in Saccharomyces cerevisiae.PLoSONE,Mar 6;10(3):e0119261, Fulltext
PMID:25747122 IF:3,2
60. Abdel-Fattah, W., Jablownski, D., Di Santo, R., Thuering, K.L., Scheidt, V., Hammermeister, A., Have, S. t., Helm, M., Schaffrath, R., Stark, M.J.R. (2015). ”Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast.€ PlosGen.Jan 8. 11(1):e1004931. Fulltext
PMID:25569479    IF:7,5
-Originals- -Reviews-
59. Krieg, B., Hirsch, M., Scholz, E., Nuhn, L., Tabujew, I., Bauer, H….,&Helm, M. (2014).New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes.€ Pharmaceutical Research. Oct 09, 32(6):1957-74, Full text  R11 Spenkuch, F., Motorin, Y., & Helm, M.(2014). Pseudouridine: Still mysterious, but never a fake (uridine)!.RNA biology, 11(12):1540-54, Full text
PMID:25488263   IF:3,4  PMID: 25616362    IF:5,0
58. Spenkuch, F., Hinze, G., Kellner, S., Kreutz, C., Micura, R., Basché, T. & Helm, M. (2014).”Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor.€ NucleicAcids Research. Oct 09, 42(20):12735-45, Full text  R10 Helm, M. & Alfonzo, JD. (2014). "Posttranscriptional RNA Modifications: Playing Metabolic Games in a Cell's Chemical Legoland. Chem. Biol., Feb. 20, 21(2):174-85, Full text
PMID:25300485   IF:9,1  PMID: 24315934    IF:6,7
57. Kellner, S., Ochel, A., Thüring, K., Spenkuch, F., Neumann, J., Sharma, S., Entian, K.D., Schneider, D. & Helm, M. (2014).”Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. NucleicAcids Research. Aug 16., 42(18):e142, Full text
PMID:25129236   IF:9,1
56. Blanco, S., Dietmann, S., Flores, J.V., Hussain, S., Kutter, C., Humphreys, P., Lukk, M., Lombard, P., Treps, L. Popis, M., Kellner, S., Hölter, S.M., Garret, L., Wurst, W., Becker, L., Klopstock, T., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Karadottir, R.T., Helm, M., Ule, J., Gleeson, J.G., Odom, D.T., Frye, M. (2014).Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.€ TheEMBO Journal, Jul 25., 33(18):2020-39, Full text
PMID: 25063673   IF:10,4
55. Kaiser, S., Rimbach, K., Eigenbrod, T., Dalpke, A.H. & Helm, M. (2014)."A modified dinucleotide motif specifies tRNA recognition by TLR7." RNA Sep.20(9):1351-5, Full text
PMID:25051971   IF:4,9
54. Fritz, T. Hirsch, M. Richter, F.C., Müller, S.S., Hofmann, A.M., Rusitzka, K.A., Markl, J., Massing, U., Frey, H. Helm, M. (2014)."Click modification of multifunctional liposomes bearing hyperbranched polyether chains." Biomacromolecules, Jul 14., 15(7):2440-8, Full text
PMID: 24805163   IF:5,8
53. KotaskovaM., Osman Oglou O., Helm, M. (2014) "Synthesis of new asymmetric xanthene dyes via catalyst-free SNAr with sulfur nucleophiles" Organic & Biomolecular Chemistry, Jun 21., 12(23):3816-20, Full text
PMID: 24802552   IF:3,6
52. Shanmugam, R., Aklujkar, M., Schäfer, M., Reinhardt, R., Nickel, O., Reuter, G., Lovley, D.R., Ehrenhofer-Murray, A., Nellen, W., Ankri, S., Helm, M. et al.(2014). "The Dnmt2 RNA methyltransferase homolog of Geobactersulfurreducens specifically methylatestRNA-Glu."Nucleic Acids Research, Apr 7., 42(10):6487-96, Full text
PMID: 24711368IF:9,1
51. Tabujew, I., Freidel, C., Krieg, B., Helm, M., Koynov, K., Müllen, K., Peneva, K. (2014). "The Guanidinium Group as a Key Part of Water-Soluble Polymer Carriers for siRNA Complexation and Protection against Degradation." Macromolecular rapid communications, Apr 4.,35(13):1191-7, Full Text
PMID: 24700561   IF:4,9
50. Buchhaupt, M., Sharma,S., Kellner, S., Oswald, S.,Paetzold, M., Pfeifer, C., Watzinger, P., Schraeder, J., Helm, M., Entian, K.D.(2014). "Partial Methylation at Am100 in 18S rRNA of Baker's Yeast Reveals Ribosome Heterogeneity on the Level of Eukaryotic rRNA Modification." PLoSOne, Feb 28, 9(2):e89640, Full text
PMID: 24586927   IF:3,2
49. Kellner, S., Neumann, J., Rosenkranz, D., Lebedeva, S., Ketting, R.F., Zischler, H., Schneider, D., & Helm, M.*(2014). "Profiling of RNA modifications by multiplexed stable isotope labelling." ChemicalCommunications.(Cambridge, England), Apr 4., 50(26):3516-8, Full text
PMID: 24567952   IF:6,8
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48. Kellner, S., Kollar, L. B., Ochel, A., Ghate, M. & Helm, M. (2013). "Structure-Function Relationship of Substituted Bromomethylcoumarins in Nucleoside Specificity of RNA Alkylation." PLoSOne. (Public Library of science), Jul 3., 8(7):e67945, Full text
PMID: 23844135   IF:3,2
47. Machnicka, M. A., Milanowska, K., Osman Oglou, O., Purta, E., Kurkowska, M., Olchowik, A., Januszewski, W., Kalinowski, S., Dunin-Horkawicz, S., Rother, K., Helm, M., Bujnicki, J. M. & Grosjean, H. (2012). "MODOMICS: a database of RNA modification pathways--2012 update." Nucleic Acids Research, Oct 30, 41(Database issue): D262-7, Full text
PMID: 23118484   IF:9,1
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46. Seidu-Larry, S., Krieg, B., Hirsch, M., Helm, M. & Domingo, O. (2012). "A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge." ChemicalCommunications (Cambridge, England), Nov 18., 48(89):11014-6, Full text  R9 Dalpke, A. & Helm, M. (2012). "RNA mediated Toll-like receptor stimulation in health and disease."RNA Biol, Jun., 9(6):828-42, Full text
PMID: 23037931   IF:6,8  PMID: 22617878 IF:5,0
45. Tuorto, F., Liebers, R., Musch, T., Schaefer, M., Hofmann, S., Kellner, S., Frye, M., Helm, M., Stoecklin, G. & Lyko, F. (2012)."RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis." Nature Structural & Molecular Biology. Sep, 19(9):900-5, Full Text
PMID: 22885326   IF:13,3
44. Jurkowski, T. P., Shanmugam, R., Helm, M. & Jeltsch, A. (2012)."Mapping the tRNA Binding Site on the Surface of Human DNMT2 Methyltransferase." Biochemistry, Jun 5., 51(22):4438-44, Full text
PMID: 22591353   IF:3,0
43. Sencilo, A., Paulin, L., Kellner, S., Helm, M. & Roine, E. (2012). "Related haloarchaeal pleomorphic viruses contain different genome types." Nucleic Acids Research, Jul 40(12):5523-34, Full Text
PMID: 22396526   IF:9,1
42. Nuhn, L., Hirsch, M., Krieg, B., Koynov, K., Fischer, K., Schmidt, M., Helm, M. & Zentel, R. (2012)."Cationic Nanohydrogel Particles as Potential siRNA Carriers for Cellular Delivery." ACS Nano, Mar 27., 6(3):2198-214, Full text
PMID: 22381078   IF:12,9
41. Gehrig, S., Eberle, M. E., Botschen, F., Rimbach, K., Eberle, F., Eigenbrod, T., Kaiser, S., Holmes, W. M., Erdmann, V. A., Sprinzl, M., Bec, G., Keith, G., Dalpke, A. H. & Helm, M.(2012)."Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity." The Journal of Experimental Medicine, Feb 13., 209(2):225-33, Full text
PMID: 22312113   IF:12,5
40. Hirsch, M., Strand, D. & Helm, M.(2012)."Dye selection for live cell imaging of intact siRNA." BiologicalChemistry , Jan, 393(1-2):23-3, Full text
PMID: 22628296   IF:3,3
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39. Kobitski, A. Y., Hengesbach, M., Seidu-Larry, S., Dammertz, K., Chow, C. S., van Aerschot, A., Nienhaus, G. U. & Helm, M. (2011). "Single-Molecule FRET Reveals a Cooperative Effect of Two Methyl Group Modifications in the Folding of Human Mitochondrial tRNA(Lys)."Chemistry & Biology , Jul 19., 18(7):928-36, Full text  R8 Motorin, Y. & Helm, M.* (2011). "RNA nucleotide methylation." Wiley Interdiscip Rev RNA, Sep.-Oct., 2(5):611-31, Full text
PMID: 21802013   IF:6,7  PMID: 21823225   IF: 6,0
38. Kellner, S., Seidu-Larry, S., Burhenne, J., Motorin, Y. & Helm, M. (2011). "A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA."NucleicAcids Research, Sep 1., 39(16):7348-60, Full text  R7 Behm-Ansmant, I., Helm, M. & Motorin, Y. (2011). "Use of specific chemical reagents for detection of modified nucleotides in RNA."J NucleicAcids, Apr. 13, 2011:408053, Full text
PMID: 21646334   IF:9,1  PMID: 21716696   IF: 8,0
37. Nguyen, T. H., Steinbock, L. J., Butt, H. J., Helm, M. & Berger, R. (2011). "Measuring single small molecule binding via rupture forces of a split aptamer." Journal of the American ChemicalSociety , Feb 23., 133(7):2025-7, Full text
PMID: 21287983   IF:12,1
36. Dammertz, K., Hengesbach, M., Helm, M., Nienhaus, G. U. & Kobitski, A. Y. (2011). "Single-molecule FRET studies of counterion effects on the free energy landscape of human mitochondriallysine tRNA." Biochemistry , Apr 19., 50(15):3107-15, Full text
PMID: 21375355   IF:3,0
35. Motorin, Y., Burhenne, J., Teimer, R., Koynov, K., Willnow, S., Weinhold, E. & Helm, M. (2011). "Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling." Nucleic Acids Research , Mar, 39(5):1943-5, Full text
PMID: 21037259   IF:9,1
-Originals- -Reviews-
34. Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M. & Lyko, F. (2010). "RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage." Genes & Development , Aug 1., 24(15):1590-5, Full Text  R6 Motorin, Y. & Helm, M.* (2010). "tRNAstabilization by modified nucleotides." Biochemistry, Jun. 22, 49(24):4934-44.
PMID: 20679393   IF:10,8 PMID: 20459084 IF: 3,0
33. Hengesbach, M., Voigts-Hoffmann, F., Hofmann, B. & Helm, M. (2010). "Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET." RNA, Mar, 16(3):610-2, Full Text  R4 Kellner, S.,Burhenne, J. & Helm, M.* (2010). "Detection of RNA modifications." RNABiol, Mar.-Apr., 7(2):237-47.
PMID: 20106954   IF:4,9 PMID:20224293 IF: 3,2
32. Tovy, A., Siman Tov, R., Gaentzsch, R., Helm, M. & Ankri, S. (2010). "A new nuclear function of the Entamoebahistolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity." PLoSPathogens , Feb 19., 6(2):e1000775, Full text  R4 Motorin, Y.,Lyko, F. & Helm, M.* (2010). "5-methylcytosine in RNA: Detection, enzymatic formation and biological functions." Nucleic Acids Res, March, 38(5):1415-30, Full text
PMID: 20174608   IF:7,6  PMID: 20007150 IF: 9,1
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31. Fuest, C., Bankstahl, M., Winter, P., Helm, M., Pekcec, A. & Potschka, H. (2009). "In vivo down-regulation of mouse brain capillary P-glycoprotein: a preliminary investigation." NeuroscienceLetters , Oct 16., 464(1):47-51, Full text  R3 Helm, M.*,Kobitski, A. & Nienhaus, G. (2009). "Single-molecule Förster resonance energy transfer studies of RNA structure, dynamics and function."BiophysicalReviews, Nov. 10,1(4): 161-176
PMID: 19679165   IF:2,0 DOI: 10.1007/s12551-009-0018-3 IF: 3,0
30. Hayrapetyan, A., Grosjean, H. & Helm, M. (2009). "Effect of a quaternary pentamine on RNA stabilization and enzymatic methylation." BiologicalChemistry , Sep, 390(9):851-6, Full text
PMID: 19558320   IF:3,3
29. Hirsch, M., Ziroli, V., Helm, M. & Massing, U. (2009). "Preparation of small amounts of sterile siRNA-liposomes with high entrapping efficiency by dual asymmetric centrifugation (DAC)." Journal of Controlled Release , Apr 2.,135(1):80-8, Full text
PMID: 19124051 IF:7,7
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28. Jurkowski, T. P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G. & Jeltsch, A. (2008). "Human DNMT2 methylatestRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism." RNA , Aug, 14(8):1663-70, Full text  R2 Kobitski, A. Y., Nierth, A., Hengesbach, M., Jaschke, A., Helm, M. & Nienhaus, G. U.* (2008). "Exploring the folding free energy landscape of small RNA molecules by single-pair Förster resonance energy transfer." Biophys. Rev.Lett, Oct., 3(4): 439-457., 
PMID: 18567810   IF:4,9 DOI: 10.1142/S1793048008000873 IF: 3,0
27. Kobitski, A. Y., Hengesbach, M., Helm, M. & Nienhaus, G. U. (2008). "Sculpting an RNA conformational energy landscape by a methyl group modification--a single-molecule FRET study." AngewandteChemie (International Ed in Englisch) 47(23):4326-30, Full text
PMID: 18449867   IF:11,3
26. Steinbock, L. J. & Helm, M. (2008). "Wavelength dependence of photoinducedmicrocantilever bending in the UV-VIS range." Sensors 8(1):23-34, Full text
doi:10.3390/s8010023   IF:2,3
25. Hengesbach, M., Meusburger, M., Lyko, F. & Helm, M. (2008). "Use of DNAzymes for site-specific analysis of ribonucleotide modifications." RNA , Jan, 14(1):180-7, Full text
PMID: 17998290   IF:4,9
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24. Voigts-Hoffmann, F., Hengesbach, M., Kobitski, A. Y., van Aerschot, A., Herdewijn, P., Nienhaus, G. U. & Helm, M. (2007). "A methyl group controls conformational equilibrium in human mitochondrial tRNA(Lys)." Journal of the American Chemical Society, Nov 7., 129(44):13382-3, Full text
PMID: 17941640   IF:12,1
23. Järve, A., Müller, J., Kim, I. H., Rohr, K., MacLean, C., Fricker, G., Massing, U., Eberle, F., Dalpke, A., Fischer, R., Trendelenburg, M. F. & Helm, M. (2007). "Surveillance of siRNA integrity by FRET imaging." Nucleic Acids Research, 35(18):e124, Full text 
PMID: 17890733   IF:9,1
22. Wehrmeister, J., Fuss, A., Saurenbach, F., Berger, R. & Helm, M. (2007). "Readout of micromechanical cantilever sensor arrays by Fabry-Perot interferometry." TheReview of ScientificInstruments, Oct, 78(10):104105, Full text
PMID: 17979440   IF:1,6
21. Kobitski, A. Y., Nierth, A., Helm, M., Jaschke, A. & Nienhaus, G. U. (2007). "Mg2+-dependent folding of a Diels-Alderase ribozyme probed by single-molecule FRET analysis." NucleicAcids Research, 35(6):2047-5, Full text
PMID: 17344321IF:9,1
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20. Maniura-Weber, K., Helm, M., Engemann, K., Eckertz, S., Mollers, M., Schauen, M., Hayrapetyan, A., von Kleist-Retzow, J. C., Lightowlers, R. N., Bindoff, L. A. & Wiesner, R. J. (2006). "Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNALeu(UUR)) gene." NucleicAcids Research 34(22):6404-15, Full text  R1 Helm, M.*(2006). "Post-transcriptional nucleotide modification and alternative folding of RNA." Nucleic Acids Res, Feb. 1,34(2):721-33, Full text
PMID: 17130166   IF:9,1 PMID:16452298 IF: 9,1
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19. Möllers, M., Maniura-Weber, K., Kiseljakovic, E., Bust, M., Hayrapetyan, A., Jaksch, M., Helm, M., Wiesner, R. J. & von Kleist-Retzow, J. C. (2005). "A new mechanism for mtDNA pathogenesis: impairment of post-transcriptional maturation leads to severe depletion of mitochondrial tRNASer(UCN) caused by T7512C and G7497A point mutations." Nucleic Acids Research , Sep 30., 33(17):5647-58, Full text
PMID: 16199753   IF:9,11
18. Kurschat, W. C., Müller, J., Wombacher, R. & Helm, M. (2005). "Optimizing splinted ligation of highly structured small RNAs." RNA , Dec, 11(12):1909-14, Full text
PMID: 16251384IF:4,9
17. Helm, M., Petermeier, M., Ge, B., Fiammengo, R. & Jäschke, A. (2005). "Allosterically activated Diels-Alder catalysis by a ribozyme." Journal of the American ChemicalSociety , Aug 3, 127(30):10492-3, Full text
PMID: 16045328   IF:12,1
16. Helm, M., Servant, J. J., Saurenbach, F. & Berger, R. (2005). "Read-out of micromechanical cantilever sensors by phase shifting interferometry." Applied Physics Letters 87(6).
doi:10.1063/ 1.2008358   IF:3,3
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15. Sissler, M., Helm, M., Frugier, M., Giege, R. & Florentz, C. (2004). "Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants." RNA, May, 10(5):841-53
PMID: 15100439   IF:4,9
14. Helm, M.& Attardi, G. (2004). "Nuclear control of cloverleaf structure of human mitochondrial tRNA(Lys)." Journal of MolecularBiology , Mar 26., 337(3):545-60, Full text
PMID: 15019776   IF:3,0
13. Asin-Cayuela, J., Helm, M. & Attardi, G. (2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity." Journal of BiologicalChemistry , Apr 9., 279(15):15670-7, Full text
PMID: 14744862   IF:4,6
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12. Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. & Marchfelder, A. (2001). "The plant tRNA 3' processing enzyme has a broad substrate spectrum." Biochemistry , Jul 27., 40(28):8264-72, Full text
PMID: 11444972   IF:3,0
11. Helm, M., Kopka, M. L., Sharma, S. K., Lown, J. W. & Giege, R. (2001). "RNase activity of a DNA minor groove binder with a minimalist catalytic motif from RNase A." Biochemical andBiophysical Research Communications , Mar, 281(5):1283-90, Full text
PMID: 11243875   IF:2,3
-Originals- -Reviews-
10. Helm, M., Brule, H., Friede, D., Giege, R., Putz, D. & Florentz, C. (2000). "Search for characteristic structural features of mammalian mitochondrial tRNAs." RNA , Oct, 6(10):1356-7, Full text
PMID: 11073213IF:4,9
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9. Helm, M., Giege, R. & Florentz, C. (1999). "A Watson-Crick base-pair-disrupting methyl group (m1A9) is sufficient for cloverleaf folding of human mitochondrial tRNALys." Biochemistry , Oct 5., 38(40):13338-46, Full text
PMID: 10529209   IF:3,0
8. Vlasov, A. V., Helm, M., Naumov, V. A., Breusov, A. A., Buneva, V. N., Florentz, C., Giege, R. & Nevinskii, G. A. (1999). "[Features of tRNA hydrolysis by autoantibodies from blood serum of patients with certain autoimmune and virus diseases]." MolekuliarnaiaBiologiia (Mosk) , Sep -Oct, 33(5):866-72
PMID: 10579192   IF:N/A
7. Vlassov, A. V., Helm, M., Florentz, C., Naumov, V. A., Breusov, A. A., Buneva, V. N., Giege, R. & Nevinsky, G. A. (1999). "Variability of Substrate Specificity of Serum Antibodies Obtained from Patients with Different Autoimmune and Viral Diseases in Reaction of tRNA Hydrolysis." RussianJournal of Immunologie , Apr, 4(1):25-32
PMID: 12687113   IF:N/A
6. Helm, M., Brule, H., Giege, R. & Florentz, C. (1999). "More mistakes by T7 RNA polymerase at the 5' ends of in vitro-transcribed RNAs." RNA , May, 5(5):618-21, Full text
PMID: 10334331   IF:4,9
5. Helm, M., Florentz, C., Chomyn, A. & Attardi, G. (1999). "Search for differences in post-transcriptional modification patterns of mitochondrial DNA-encoded wild-type and mutant human tRNALys and tRNALeu(UUR)." NucleicAcids Research , Feb 1., 27(3):756-63, Full text
PMID: 9889270   IF:9,1
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4. Degoul, F., Brule, H., Cepanec, C., Helm, M., Marsac, C., Leroux, J., Giege, R. & Florentz, C. (1998). "Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene." Human Molecular Genetics , Mar, 7(3):347-54, Full text
PMID: 9466989   IF:6,4
3. Vlassov, A., Florentz, C., Helm, M., Naumov, V., Buneva, V., Nevinsky, G. & Giege, R. (1998). "Characterization and selectivity of catalytic antibodies from human serum with RNase activity." NucleicAcids Research, Dec 1., 26(23):5243-50, Full text
PMID: 9826744   IF:9,1
2. Frugier, M., Helm, M., Felden, B., Giege, R. & Florentz, C. (1998). "Sequences outside recognition sets are not neutral for tRNAaminoacylation. Evidence for nonpermissive combinations of nucleotides in the acceptor stem of yeast tRNAPhe." TheJournal of BiologicalChemistry , May 8., 273(19):11605-10, Full text
PMID: 9565578   IF:4,8
1. Helm, M., Brule, H., Degoul, F., Cepanec, C., Leroux, J. P., Giege, R. & Florentz, C. (1998). "The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA." NucleicAcids Research ,Apr 1., 26(7):1636-43, Full text
PMID: 9512533   IF:9,1