Original Arbeiten und Reviews

--2018--
-Originals- -Reviews-
94. Keller, P., Freund, I., Marchand, V., Bec, G., Huang, R., Motorin, Y., Eigenbrod, T., Dalpke, A., Helm, M.,
Double methylation of tRNA-U54 to 2'-O-methylthymidine (TM) synergistically decreases immune response by Toll-like receptor 7., (2018), Nucleic Acids Res., Aug. 8, Epub ahead of print, Full text
PMID: 30102387 IF: N/A
93. Dal Magro, C., Keller, P., Kotter, A., Werner, S., Duarte, V., Marchand, V., Ignarski, M., Freiwald, A., Müller, R.U., Dietrich, C., Motorin, Y., Butter, F., Atta, M., Helm, M.,
A vastly increased chemical variety of RNA modifications that includes a thioacetal structure, (2018), Angew. Chem. Int. Ed. Engl., Apr. 6, 57(26):7893-7897, Full text
PMID: 29624844 IF: 12
92. Knuckles, P., Lence, T., Haussmann, I. U., Jacob, D., Kreim, N., Carl, S.H., Masiello, I., Hares, T., Villaseñor, R., Hess, D., Andrade-Navarro, M.A., Biggiogera, M., Helm, M., Soller, M., Bühler, M., Roignant, J.Y.,
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d., (2018), Genes Dev., Mar. 13, 32 (5-6):415-429, Full text
PMID: 29535189 IF: 9,4
91. Aschenbrenner, J., Werner, S., Marchand, V., Adam, M., Motorin , Y., Helm, M., Marx, A., Engineering of a DNA polymerase for direct m6A Sequencing, (2018), Angew. Chem. Int. Ed. Engl., Jan. 8, 57,417-421. Full Text
PMID: 29115744 IF:12
--2017--
-Originals- -Reviews-
90. Boccaletto, P., Machnicka, M.A., Purta, E., Piatkowski, P., Baginski, B., Wirecki, T.K., de Crécy-Lagard, V., Ross, R., Limbach, P.A., Kotter, A., Helm, M., Bujnicki, J.M., MODOMICS: a database of RNA modification Pathways. 2017 update., (2017), Nucleic Acid Research., Nov. 2, 46(D1):D303-D307, Full Text R14 Helm, M., Motorin, Y.,Detecting RNA modifications in the epitranscriptome: predict and validate, (2017), Nature Reviews Genetics, Feb. 20, Full text
PMID: 29106616  IF:10,2 PMID: 28216634 http://rdcu.be/wqhI IF: N/A
89. Negwer, I., Hirsch, M., Kaloyanova, S., Brown, T., Peneva, K., Butt, H.J., Koynov, K., Helm, M., Modulation of Mitochondriotropic Properties of Cyanine Dyes by in Organello Copper-Free Click Reaction., (2017), Chembiochem., Sep. 19, 18(18):1814-1818, Full Text
PMID: 28704573  IF:2,8
88. Weber, B., Kappel, C., Scherer, M., Helm, M., Bros. M., Grabbe, S., Barz, M., PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes., (2017), Macromol Biosci., Jul. 31, 17(10), Full Text
PMID: 28759159  IF:3,3
87. Legrand, C., Tuorto, F., Hartmann, M., Liebers, R., Jacob, D., Helm, M., Lyko, F., Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs, (2017), Genome Res., Jul. 6, 27(9):1589-1596, Full text
PMID: 28684555  IF:11,9
86. Schmitt, F.C.F., Freund, I., Weigand, M.A., Helm, M., Dalpke, A.H., Eigenbrod, T., Identification of an optimized 2'-O-methylated tri-nucleotide RNA motif inhibiting Toll-like receptor 7 and 8, (2017), RNA, Jun. 2, 23(9):1344-1351, Full text
PMID: 28576825 IF:4,6
85. Hellmuth, I., Freund, I., Schlöder, J., Seidu-Larry, S., Thüring, K., Slama, K., Langhanki, J., Kaloyanova, S., Eigenbrod, T., Krumb, M., Röhm, S., Peneva K., Opatz, T., Jonuleit, H., Dalpke, A.H., Helm, M., Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor, (2017), 7. Fronti. Immunol., Mar. 24, 8:312, Full text
DOI: 10.3389/fimmu.2017.00312 IF:5,7
84. Schmid, K., Adobes-Vidal, M., Helm, M., Alkyne-Functionalized Coumarin Compound for Analytic and Preparative 4-Thiouridine Labeling, (2017), Bioconjugate Chemistry, Mar. 15, 28(4):1123-1134, Full text
PMID: 28263563 IF:4,5
83. Marchand, V., Pichot, F., Thüring, K., Avadi, L., Freund, I., Dalpke, A., Helm, M., Motorin, Y., Next-Generation Sequencing-Based RiboMethSeq Protocol for Analysis of tRNA 2'-O-Methylation, (2017), Biomolecules, Feb. 9, 7(1), Full Text
PMID: 28208788 IF:N/A
--2016--
-Originals- -Reviews-
82. Lence, T., Akhtar, J., Bayer, M., Schmid, K., Spindler, K., Ho, CH., Kreim, N., Andrade-Navarro, MA., Poeck, B., Helm, M., Roignant, JY., m6A modulates neuronal functions and sex determination in Drosophila, (2016), Nature, Dec. 8, 540(7632):242-247, Full text R13 Motorin, Y., Seidu-Larry, S., Helm, M., (2016) DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position. Adv Exp Med Biol., 945:19-33. Full text
PMID: 27919077 IF:38,2 PMID: 27826833 IF: N/A
81. Kaiser, S., Jurkowski, TP., Kellner, S., Schneider, D., Jeltsch, A., Helm, M., The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA, (2016)RNA Biology, Nov., 7:1-11, Full text R12 Jeltsch, A., Ehrenhofer-Murray, A., Jurkowski, TP., Lyko, F., Reuter, G., Ankri, S., Nellen, W., Schaefer, M., Helm, M. Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation, (2016) RNA Biology., Sep. 2, 14(9):1108-1123, Full Text
PMID: 27819523 IF:4,1 PMID: 27232191 IF: N/A
80. Hauenschild, R., Werner, S., Tserovski, L., Hildebrandt, A., Motorin, Y., Helm, M., CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles, (2016)Biomolecues., Nov. 10, 6(4), Full text
PMID: 27834909 IF:N/A
79. Falckenhayn, C., Carneiro, VC., de Mendonça Amarante, A., Schmid, K., Hanna, K., Kang, S., Helm, M., Dimopoulos, G., Fantappié, MR., Lyko, F., Comprehensive DNA methylation analysis of the Aedes aegypti genome, (2016) Sci. Rep., Nov. 2, 6:36444, Full text
PMID: 27805064 IF:5,2
78. Jüdes, A., Bruch, A., Klassen, R., Helm, M., Schaffrath, R., Sulfur transfer and activation by ubiquitin-like modifier system Uba4Urm1 link protein urmylation and tRNA thiolation in yeast, (2016), Microb Cell., Oct. 24, 3(11):554-564, Full text
PMID: 28357324   IF:N/A
77. Müller, S., Fritz, T., Gimnich, M., Worm, M., Helm, M., Frey, H., Biodegradable Hyperbranched Polyether-Lipids with In-Chain pH-Sensitive Linkages, (2016) Polym. Chem., Sep. 19, Full text
DOI: 10.1039/C6PY01308B   IF:5,7
76. Tserovski, L., Helm, M.,Diastereoselectivity of 5-methyluridine osmylation is inverted inside an RNA chain., (2016)Bioconjugate Chemistry, Aug. 19, 27(9):2188-97, Full text
PMID: 27540864   IF:4,5
75. Fritz, T., Voigt, M., Worm, M., Negwer, I., Müller, SS., Kettenbach, K., Ross, TL., Roesch, F., Koynov, K., Frey, H., Helm, M., Orthogonal Click Conjugation to the Liposomal Surface Reveals the Stability of the Lipid Anchorage as Crucial for Targeting., (2016)Chemistry, Aug. 8, 22(33):11578-82
PMID: 27403892  IF:5,8
74. Nick, TA., de Oliverira, TE., Pilat, DW., Spenkuch, F., Butt, HJ., Helm, M., Netz, PA., Berger, R., Stability of a Split Streptomycin Binding Aptamer., (2016)The Journal of physical chemistry. B., Jul. 14, 120(27):6479-89 , Full text
PMID: 27281393   IF:3,2
73. Marchand, V., Blanloeil- Oillo, F., Helm, M., Motorin, Y., Illumina-based RiboMethSeq approach for mapping of 2'-O-Me residues in RNA., (2016)Nucleic Acid Research, Jun. 14, 44(16):e135, Full text
PMID: 27302133  IF:9,1
--2015--
-Originals- -Reviews-
72. Kienhöfer, S., Musheev, MU., Stapf, U., Helm, M., Schomacher, L., Niehrs, C., Schäfer, A., (2015) GADD45a physically and functionally interacts with TET1. Differentiation, Nov. 03, 90(1-3):59-68, Full text
PMID: 26546041    IF:3,4
71. Vogt, G., Falckenhayn, C., Schrimpf, A., Schmid, K., Hanna, K., Pantelein, J., Helm, M., Schulz, R., Lyko, F., (2015) The marbled crayfish as a paradigm for saltational speciation by autopolyploidy and parthenogenesis in animals. Biology Open, Oct. 30, 4(11):1583-94, Full Text
PMID: 26519519    IF:2,4
70. Müller, M., Hartmann, M., Schuster, I., Bender, S., Thüring, KL., Helm, M., Katze, JR., Nellen, W., Lyko, F., Ehrenhofer-Murray, AE. (2015) Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine.Nucleic Acids Research, Sep. 30, 43(22):10952-62, Fulltext
PMID: 26424849    IF:9,1
69. Hauenschild, R., Tserovski, L., Schmid, K., Thüring, K., Winz, ML., Sharma, S., Entian, KD., Wacheul, L., Lafontaine, DL., Anderson, J., Alfonzo, J., Hildebrandt, A., Jäschke, A., Motorin, Y., Helm, M., (2015) The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent.Nucleic Acids Research, Sep. 13, 43(20):9950-64, Fulltext
PMID: 26365242   IF:9,1
68. Schmid, K., Thüring, K., Keller, P., Ochel, A., Kellner, S., Helm, M., (2015) Variable presence of 5-methylcytosine in commercial RNA and DNA.RNA Biology, Aug. 14, 12(10):1152-8, Full text
PMID: 26274337    IF:5,0
67. Bourgeois, G., Ney, M., Gaspar, I., Aiqueperse, C., Schaefer, M., Kellner, S., Helm, M., Motorin, Y. (2015) Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120. PLoS One, Jul. 21, 10(7):e0133321, Fulltext
PMID: 26196125    IF:3,2
66. Shanmugam, R., Fierer, J., Kaiser, S., Helm, M., Jurkowski, T. P., Jeltsch, A. (2015) Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences.CellDiscovery, Jun. 9, 1, 15010, Fulltext
doi:10.1038/celldisc.2015.10   IF:N/A
65. Domingo,O., Hellmuth, I., Jaeschke, A., Kreutz, C., Helm, M. (2015) Intermolecular 'cross-torque': the N4-cytosine propargyl residue is rotated to the 'CH'-edge as a result of Watson-Crick interaction. NucleicAcids Research, Apr. 30, 43(11):5275-83, Full text
PMID: 25934805    IF:9,1
64. Hirsch, M. & Helm, M. (2015) Live cell imaging of duplex siRNA intracellular trafficking. NucleicAcids Research, Apr. 13, 43(9):4650-60, Full text
PMID: 25870407    IF:9,1
63. Rimbach, K., Kaiser, S., Helm, M., Dalpke, A.H., Eigenbrod, T. (2015).2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells.Journale of innate immunity. Mar. 20, 7(5):482-93, Fulltext
PMID: 25823462    IF:4,4
62. Juedes, A., Ebert, F., Baer, C., Thuering, K. L., Harrer, A., Klassen, R., Helm, M. & Schaffrath, R. (2015).Urmylationand tRNAthiolation functions of ubiquitin-like Uba4 Urm1 systems are conserved from yeast to man. FEBS letters, Mar. 03, 589(8):904-9, Full text
PMID:25747390    IF:9,1
61. Klassen, R., Grunewald, P., Thuering, K. L., Eichler, C., Helm, M., & Schaffrath, R. (2015).Loss of Anticodon Wobble Uridine Modifications Affects tRNALys Function and Protein Levels in Saccharomyces cerevisiae.PLoSONE,Mar 6;10(3):e0119261, Fulltext
PMID:25747122 IF:3,2
60. Abdel-Fattah, W., Jablownski, D., Di Santo, R., Thuering, K.L., Scheidt, V., Hammermeister, A., Have, S. t., Helm, M., Schaffrath, R., Stark, M.J.R. (2015). ”Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast.€ PlosGen.Jan 8. 11(1):e1004931. Fulltext
PMID:25569479    IF:7,5
--2014--
-Originals- -Reviews-
59. Krieg, B., Hirsch, M., Scholz, E., Nuhn, L., Tabujew, I., Bauer, H….,&Helm, M. (2014).New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes.€ Pharmaceutical Research. Oct 09, 32(6):1957-74, Full text  R11 Spenkuch, F., Motorin, Y., & Helm, M.(2014). Pseudouridine: Still mysterious, but never a fake (uridine)!.RNA biology, 11(12):1540-54, Full text
PMID:25488263   IF:3,4  PMID: 25616362    IF:5,0
58. Spenkuch, F., Hinze, G., Kellner, S., Kreutz, C., Micura, R., Basché, T. & Helm, M. (2014).”Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor.€ NucleicAcids Research. Oct 09, 42(20):12735-45, Full text  R10 Helm, M. & Alfonzo, JD. (2014). "Posttranscriptional RNA Modifications: Playing Metabolic Games in a Cell's Chemical Legoland. Chem. Biol., Feb. 20, 21(2):174-85, Full text
PMID:25300485   IF:9,1  PMID: 24315934    IF:6,7
57. Kellner, S., Ochel, A., Thüring, K., Spenkuch, F., Neumann, J., Sharma, S., Entian, K.D., Schneider, D. & Helm, M. (2014).”Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. NucleicAcids Research. Aug 16., 42(18):e142, Full text
PMID:25129236   IF:9,1
56. Blanco, S., Dietmann, S., Flores, J.V., Hussain, S., Kutter, C., Humphreys, P., Lukk, M., Lombard, P., Treps, L. Popis, M., Kellner, S., Hölter, S.M., Garret, L., Wurst, W., Becker, L., Klopstock, T., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Karadottir, R.T., Helm, M., Ule, J., Gleeson, J.G., Odom, D.T., Frye, M. (2014).Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.€ TheEMBO Journal, Jul 25., 33(18):2020-39, Full text
PMID: 25063673   IF:10,4
55. Kaiser, S., Rimbach, K., Eigenbrod, T., Dalpke, A.H. & Helm, M. (2014)."A modified dinucleotide motif specifies tRNA recognition by TLR7." RNA Sep.20(9):1351-5, Full text
PMID:25051971   IF:4,9
54. Fritz, T. Hirsch, M. Richter, F.C., Müller, S.S., Hofmann, A.M., Rusitzka, K.A., Markl, J., Massing, U., Frey, H. Helm, M. (2014)."Click modification of multifunctional liposomes bearing hyperbranched polyether chains." Biomacromolecules, Jul 14., 15(7):2440-8, Full text
PMID: 24805163   IF:5,8
53. KotaskovaM., Osman Oglou O., Helm, M. (2014) "Synthesis of new asymmetric xanthene dyes via catalyst-free SNAr with sulfur nucleophiles" Organic & Biomolecular Chemistry, Jun 21., 12(23):3816-20, Full text
PMID: 24802552   IF:3,6
52. Shanmugam, R., Aklujkar, M., Schäfer, M., Reinhardt, R., Nickel, O., Reuter, G., Lovley, D.R., Ehrenhofer-Murray, A., Nellen, W., Ankri, S., Helm, M. et al.(2014). "The Dnmt2 RNA methyltransferase homolog of Geobactersulfurreducens specifically methylatestRNA-Glu."Nucleic Acids Research, Apr 7., 42(10):6487-96, Full text
PMID: 24711368IF:9,1
51. Tabujew, I., Freidel, C., Krieg, B., Helm, M., Koynov, K., Müllen, K., Peneva, K. (2014). "The Guanidinium Group as a Key Part of Water-Soluble Polymer Carriers for siRNA Complexation and Protection against Degradation." Macromolecular rapid communications, Apr 4.,35(13):1191-7, Full Text
PMID: 24700561   IF:4,9
50. Buchhaupt, M., Sharma,S., Kellner, S., Oswald, S.,Paetzold, M., Pfeifer, C., Watzinger, P., Schraeder, J., Helm, M., Entian, K.D.(2014). "Partial Methylation at Am100 in 18S rRNA of Baker's Yeast Reveals Ribosome Heterogeneity on the Level of Eukaryotic rRNA Modification." PLoSOne, Feb 28, 9(2):e89640, Full text
PMID: 24586927   IF:3,2
49. Kellner, S., Neumann, J., Rosenkranz, D., Lebedeva, S., Ketting, R.F., Zischler, H., Schneider, D., & Helm, M.*(2014). "Profiling of RNA modifications by multiplexed stable isotope labelling." ChemicalCommunications.(Cambridge, England), Apr 4., 50(26):3516-8, Full text
PMID: 24567952   IF:6,8
--2013--
-Originals- -Reviews-
48. Kellner, S., Kollar, L. B., Ochel, A., Ghate, M. & Helm, M. (2013). "Structure-Function Relationship of Substituted Bromomethylcoumarins in Nucleoside Specificity of RNA Alkylation." PLoSOne. (Public Library of science), Jul 3., 8(7):e67945, Full text
PMID: 23844135   IF:3,2
47. Machnicka, M. A., Milanowska, K., Osman Oglou, O., Purta, E., Kurkowska, M., Olchowik, A., Januszewski, W., Kalinowski, S., Dunin-Horkawicz, S., Rother, K., Helm, M., Bujnicki, J. M. & Grosjean, H. (2012). "MODOMICS: a database of RNA modification pathways--2012 update." Nucleic Acids Research, Oct 30, 41(Database issue): D262-7, Full text
PMID: 23118484   IF:9,1
--2012--
-Originals- -Reviews-
46. Seidu-Larry, S., Krieg, B., Hirsch, M., Helm, M. & Domingo, O. (2012). "A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge." ChemicalCommunications (Cambridge, England), Nov 18., 48(89):11014-6, Full text  R9 Dalpke, A. & Helm, M. (2012). "RNA mediated Toll-like receptor stimulation in health and disease."RNA Biol, Jun., 9(6):828-42, Full text
PMID: 23037931   IF:6,8  PMID: 22617878 IF:5,0
45. Tuorto, F., Liebers, R., Musch, T., Schaefer, M., Hofmann, S., Kellner, S., Frye, M., Helm, M., Stoecklin, G. & Lyko, F. (2012)."RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis." Nature Structural & Molecular Biology. Sep, 19(9):900-5, Full Text
PMID: 22885326   IF:13,3
44. Jurkowski, T. P., Shanmugam, R., Helm, M. & Jeltsch, A. (2012)."Mapping the tRNA Binding Site on the Surface of Human DNMT2 Methyltransferase." Biochemistry, Jun 5., 51(22):4438-44, Full text
PMID: 22591353   IF:3,0
43. Sencilo, A., Paulin, L., Kellner, S., Helm, M. & Roine, E. (2012). "Related haloarchaeal pleomorphic viruses contain different genome types." Nucleic Acids Research, Jul 40(12):5523-34, Full Text
PMID: 22396526   IF:9,1
42. Nuhn, L., Hirsch, M., Krieg, B., Koynov, K., Fischer, K., Schmidt, M., Helm, M. & Zentel, R. (2012)."Cationic Nanohydrogel Particles as Potential siRNA Carriers for Cellular Delivery." ACS Nano, Mar 27., 6(3):2198-214, Full text
PMID: 22381078   IF:12,9
41. Gehrig, S., Eberle, M. E., Botschen, F., Rimbach, K., Eberle, F., Eigenbrod, T., Kaiser, S., Holmes, W. M., Erdmann, V. A., Sprinzl, M., Bec, G., Keith, G., Dalpke, A. H. & Helm, M.(2012)."Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity." The Journal of Experimental Medicine, Feb 13., 209(2):225-33, Full text
PMID: 22312113   IF:12,5
40. Hirsch, M., Strand, D. & Helm, M.(2012)."Dye selection for live cell imaging of intact siRNA." BiologicalChemistry , Jan, 393(1-2):23-3, Full text
PMID: 22628296   IF:3,3
--2011--
-Originals- -Reviews-
39. Kobitski, A. Y., Hengesbach, M., Seidu-Larry, S., Dammertz, K., Chow, C. S., van Aerschot, A., Nienhaus, G. U. & Helm, M. (2011). "Single-Molecule FRET Reveals a Cooperative Effect of Two Methyl Group Modifications in the Folding of Human Mitochondrial tRNA(Lys)."Chemistry & Biology , Jul 19., 18(7):928-36, Full text  R8 Motorin, Y. & Helm, M.* (2011). "RNA nucleotide methylation." Wiley Interdiscip Rev RNA, Sep.-Oct., 2(5):611-31, Full text
PMID: 21802013   IF:6,7  PMID: 21823225   IF: 6,0
38. Kellner, S., Seidu-Larry, S., Burhenne, J., Motorin, Y. & Helm, M. (2011). "A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA."NucleicAcids Research, Sep 1., 39(16):7348-60, Full text  R7 Behm-Ansmant, I., Helm, M. & Motorin, Y. (2011). "Use of specific chemical reagents for detection of modified nucleotides in RNA."J NucleicAcids, Apr. 13, 2011:408053, Full text
PMID: 21646334   IF:9,1  PMID: 21716696   IF: 8,0
37. Nguyen, T. H., Steinbock, L. J., Butt, H. J., Helm, M. & Berger, R. (2011). "Measuring single small molecule binding via rupture forces of a split aptamer." Journal of the American ChemicalSociety , Feb 23., 133(7):2025-7, Full text
PMID: 21287983   IF:12,1
36. Dammertz, K., Hengesbach, M., Helm, M., Nienhaus, G. U. & Kobitski, A. Y. (2011). "Single-molecule FRET studies of counterion effects on the free energy landscape of human mitochondriallysine tRNA." Biochemistry , Apr 19., 50(15):3107-15, Full text
PMID: 21375355   IF:3,0
35. Motorin, Y., Burhenne, J., Teimer, R., Koynov, K., Willnow, S., Weinhold, E. & Helm, M. (2011). "Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling." Nucleic Acids Research , Mar, 39(5):1943-5, Full text
PMID: 21037259   IF:9,1
--2010--
-Originals- -Reviews-
34. Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M. & Lyko, F. (2010). "RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage." Genes & Development , Aug 1., 24(15):1590-5, Full Text  R6 Motorin, Y. & Helm, M.* (2010). "tRNAstabilization by modified nucleotides." Biochemistry, Jun. 22, 49(24):4934-44.
PMID: 20679393   IF:10,8 PMID: 20459084 IF: 3,0
33. Hengesbach, M., Voigts-Hoffmann, F., Hofmann, B. & Helm, M. (2010). "Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET." RNA, Mar, 16(3):610-2, Full Text  R4 Kellner, S.,Burhenne, J. & Helm, M.* (2010). "Detection of RNA modifications." RNABiol, Mar.-Apr., 7(2):237-47.
PMID: 20106954   IF:4,9 PMID:20224293 IF: 3,2
32. Tovy, A., Siman Tov, R., Gaentzsch, R., Helm, M. & Ankri, S. (2010). "A new nuclear function of the Entamoebahistolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity." PLoSPathogens , Feb 19., 6(2):e1000775, Full text  R4 Motorin, Y.,Lyko, F. & Helm, M.* (2010). "5-methylcytosine in RNA: Detection, enzymatic formation and biological functions." Nucleic Acids Res, March, 38(5):1415-30, Full text
PMID: 20174608   IF:7,6  PMID: 20007150 IF: 9,1
--2009--
-Originals- -Reviews-
31. Fuest, C., Bankstahl, M., Winter, P., Helm, M., Pekcec, A. & Potschka, H. (2009). "In vivo down-regulation of mouse brain capillary P-glycoprotein: a preliminary investigation." NeuroscienceLetters , Oct 16., 464(1):47-51, Full text  R3 Helm, M.*,Kobitski, A. & Nienhaus, G. (2009). "Single-molecule Förster resonance energy transfer studies of RNA structure, dynamics and function."BiophysicalReviews, Nov. 10,1(4): 161-176
PMID: 19679165   IF:2,0 DOI: 10.1007/s12551-009-0018-3 IF: 3,0
30. Hayrapetyan, A., Grosjean, H. & Helm, M. (2009). "Effect of a quaternary pentamine on RNA stabilization and enzymatic methylation." BiologicalChemistry , Sep, 390(9):851-6, Full text
PMID: 19558320   IF:3,3
29. Hirsch, M., Ziroli, V., Helm, M. & Massing, U. (2009). "Preparation of small amounts of sterile siRNA-liposomes with high entrapping efficiency by dual asymmetric centrifugation (DAC)." Journal of Controlled Release , Apr 2.,135(1):80-8, Full text
PMID: 19124051 IF:7,7
--2008--
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28. Jurkowski, T. P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G. & Jeltsch, A. (2008). "Human DNMT2 methylatestRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism." RNA , Aug, 14(8):1663-70, Full text  R2 Kobitski, A. Y., Nierth, A., Hengesbach, M., Jaschke, A., Helm, M. & Nienhaus, G. U.* (2008). "Exploring the folding free energy landscape of small RNA molecules by single-pair Förster resonance energy transfer." Biophys. Rev.Lett, Oct., 3(4): 439-457., 
PMID: 18567810   IF:4,9 DOI: 10.1142/S1793048008000873 IF: 3,0
27. Kobitski, A. Y., Hengesbach, M., Helm, M. & Nienhaus, G. U. (2008). "Sculpting an RNA conformational energy landscape by a methyl group modification--a single-molecule FRET study." AngewandteChemie (International Ed in Englisch) 47(23):4326-30, Full text
PMID: 18449867   IF:11,3
26. Steinbock, L. J. & Helm, M. (2008). "Wavelength dependence of photoinducedmicrocantilever bending in the UV-VIS range." Sensors 8(1):23-34, Full text
doi:10.3390/s8010023   IF:2,3
25. Hengesbach, M., Meusburger, M., Lyko, F. & Helm, M. (2008). "Use of DNAzymes for site-specific analysis of ribonucleotide modifications." RNA , Jan, 14(1):180-7, Full text
PMID: 17998290   IF:4,9
--2007--
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24. Voigts-Hoffmann, F., Hengesbach, M., Kobitski, A. Y., van Aerschot, A., Herdewijn, P., Nienhaus, G. U. & Helm, M. (2007). "A methyl group controls conformational equilibrium in human mitochondrial tRNA(Lys)." Journal of the American Chemical Society, Nov 7., 129(44):13382-3, Full text
PMID: 17941640   IF:12,1
23. Järve, A., Müller, J., Kim, I. H., Rohr, K., MacLean, C., Fricker, G., Massing, U., Eberle, F., Dalpke, A., Fischer, R., Trendelenburg, M. F. & Helm, M. (2007). "Surveillance of siRNA integrity by FRET imaging." Nucleic Acids Research, 35(18):e124, Full text 
PMID: 17890733   IF:9,1
22. Wehrmeister, J., Fuss, A., Saurenbach, F., Berger, R. & Helm, M. (2007). "Readout of micromechanical cantilever sensor arrays by Fabry-Perot interferometry." TheReview of ScientificInstruments, Oct, 78(10):104105, Full text
PMID: 17979440   IF:1,6
21. Kobitski, A. Y., Nierth, A., Helm, M., Jaschke, A. & Nienhaus, G. U. (2007). "Mg2+-dependent folding of a Diels-Alderase ribozyme probed by single-molecule FRET analysis." NucleicAcids Research, 35(6):2047-5, Full text
PMID: 17344321IF:9,1
--2006--
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20. Maniura-Weber, K., Helm, M., Engemann, K., Eckertz, S., Mollers, M., Schauen, M., Hayrapetyan, A., von Kleist-Retzow, J. C., Lightowlers, R. N., Bindoff, L. A. & Wiesner, R. J. (2006). "Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNALeu(UUR)) gene." NucleicAcids Research 34(22):6404-15, Full text  R1 Helm, M.*(2006). "Post-transcriptional nucleotide modification and alternative folding of RNA." Nucleic Acids Res, Feb. 1,34(2):721-33, Full text
PMID: 17130166   IF:9,1 PMID:16452298 IF: 9,1
--2005--
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19. Möllers, M., Maniura-Weber, K., Kiseljakovic, E., Bust, M., Hayrapetyan, A., Jaksch, M., Helm, M., Wiesner, R. J. & von Kleist-Retzow, J. C. (2005). "A new mechanism for mtDNA pathogenesis: impairment of post-transcriptional maturation leads to severe depletion of mitochondrial tRNASer(UCN) caused by T7512C and G7497A point mutations." Nucleic Acids Research , Sep 30., 33(17):5647-58, Full text
PMID: 16199753   IF:9,11
18. Kurschat, W. C., Müller, J., Wombacher, R. & Helm, M. (2005). "Optimizing splinted ligation of highly structured small RNAs." RNA , Dec, 11(12):1909-14, Full text
PMID: 16251384IF:4,9
17. Helm, M., Petermeier, M., Ge, B., Fiammengo, R. & Jäschke, A. (2005). "Allosterically activated Diels-Alder catalysis by a ribozyme." Journal of the American ChemicalSociety , Aug 3, 127(30):10492-3, Full text
PMID: 16045328   IF:12,1
16. Helm, M., Servant, J. J., Saurenbach, F. & Berger, R. (2005). "Read-out of micromechanical cantilever sensors by phase shifting interferometry." Applied Physics Letters 87(6).
doi:10.1063/ 1.2008358   IF:3,3
--2004--
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15. Sissler, M., Helm, M., Frugier, M., Giege, R. & Florentz, C. (2004). "Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants." RNA, May, 10(5):841-53
PMID: 15100439   IF:4,9
14. Helm, M.& Attardi, G. (2004). "Nuclear control of cloverleaf structure of human mitochondrial tRNA(Lys)." Journal of MolecularBiology , Mar 26., 337(3):545-60, Full text
PMID: 15019776   IF:3,0
13. Asin-Cayuela, J., Helm, M. & Attardi, G. (2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity." Journal of BiologicalChemistry , Apr 9., 279(15):15670-7, Full text
PMID: 14744862   IF:4,6
--2001--
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12. Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. & Marchfelder, A. (2001). "The plant tRNA 3' processing enzyme has a broad substrate spectrum." Biochemistry , Jul 27., 40(28):8264-72, Full text
PMID: 11444972   IF:3,0
11. Helm, M., Kopka, M. L., Sharma, S. K., Lown, J. W. & Giege, R. (2001). "RNase activity of a DNA minor groove binder with a minimalist catalytic motif from RNase A." Biochemical andBiophysical Research Communications , Mar, 281(5):1283-90, Full text
PMID: 11243875   IF:2,3
--2000--
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10. Helm, M., Brule, H., Friede, D., Giege, R., Putz, D. & Florentz, C. (2000). "Search for characteristic structural features of mammalian mitochondrial tRNAs." RNA , Oct, 6(10):1356-7, Full text
PMID: 11073213IF:4,9
--1999--
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9. Helm, M., Giege, R. & Florentz, C. (1999). "A Watson-Crick base-pair-disrupting methyl group (m1A9) is sufficient for cloverleaf folding of human mitochondrial tRNALys." Biochemistry , Oct 5., 38(40):13338-46, Full text
PMID: 10529209   IF:3,0
8. Vlasov, A. V., Helm, M., Naumov, V. A., Breusov, A. A., Buneva, V. N., Florentz, C., Giege, R. & Nevinskii, G. A. (1999). "[Features of tRNA hydrolysis by autoantibodies from blood serum of patients with certain autoimmune and virus diseases]." MolekuliarnaiaBiologiia (Mosk) , Sep -Oct, 33(5):866-72
PMID: 10579192   IF:N/A
7. Vlassov, A. V., Helm, M., Florentz, C., Naumov, V. A., Breusov, A. A., Buneva, V. N., Giege, R. & Nevinsky, G. A. (1999). "Variability of Substrate Specificity of Serum Antibodies Obtained from Patients with Different Autoimmune and Viral Diseases in Reaction of tRNA Hydrolysis." RussianJournal of Immunologie , Apr, 4(1):25-32
PMID: 12687113   IF:N/A
6. Helm, M., Brule, H., Giege, R. & Florentz, C. (1999). "More mistakes by T7 RNA polymerase at the 5' ends of in vitro-transcribed RNAs." RNA , May, 5(5):618-21, Full text
PMID: 10334331   IF:4,9
5. Helm, M., Florentz, C., Chomyn, A. & Attardi, G. (1999). "Search for differences in post-transcriptional modification patterns of mitochondrial DNA-encoded wild-type and mutant human tRNALys and tRNALeu(UUR)." NucleicAcids Research , Feb 1., 27(3):756-63, Full text
PMID: 9889270   IF:9,1
--1998--
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4. Degoul, F., Brule, H., Cepanec, C., Helm, M., Marsac, C., Leroux, J., Giege, R. & Florentz, C. (1998). "Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene." Human Molecular Genetics , Mar, 7(3):347-54, Full text
PMID: 9466989   IF:6,4
3. Vlassov, A., Florentz, C., Helm, M., Naumov, V., Buneva, V., Nevinsky, G. & Giege, R. (1998). "Characterization and selectivity of catalytic antibodies from human serum with RNase activity." NucleicAcids Research, Dec 1., 26(23):5243-50, Full text
PMID: 9826744   IF:9,1
2. Frugier, M., Helm, M., Felden, B., Giege, R. & Florentz, C. (1998). "Sequences outside recognition sets are not neutral for tRNAaminoacylation. Evidence for nonpermissive combinations of nucleotides in the acceptor stem of yeast tRNAPhe." TheJournal of BiologicalChemistry , May 8., 273(19):11605-10, Full text
PMID: 9565578   IF:4,8
1. Helm, M., Brule, H., Degoul, F., Cepanec, C., Leroux, J. P., Giege, R. & Florentz, C. (1998). "The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA." NucleicAcids Research ,Apr 1., 26(7):1636-43, Full text
PMID: 9512533   IF:9,1